Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trial
<p><strong>Objectives</strong> To explore the effectiveness of a theory-based behavioral lifestyle intervention on health behaviors and quality of life in endometrial cancer survivors.’</p> <p><strong>Methods</strong> This was a secondary analysis of a rando...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
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BMJ Publishing Group
2019
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| _version_ | 1826269413606686720 |
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| author | Koutoukidis, D Beeken, R Manchanda, R Burnell, M Ziaudeen, N Michalopoulou, M Knobf, M Lanceley, A |
| author_facet | Koutoukidis, D Beeken, R Manchanda, R Burnell, M Ziaudeen, N Michalopoulou, M Knobf, M Lanceley, A |
| author_sort | Koutoukidis, D |
| collection | OXFORD |
| description | <p><strong>Objectives</strong> To explore the effectiveness of a theory-based behavioral lifestyle intervention on health behaviors and quality of life in endometrial cancer survivors.’</p> <p><strong>Methods</strong> This was a secondary analysis of a randomized controlled pilot trial conducted in two UK hospitals enrolling disease-free stage I-IVA endometrial cancer survivors. Participants were allocated to an 8-week group-based healthy eating and physical activity intervention or usual care using 1:1 minimization. Participants were followed up at 8 and 24 weeks, with the 8-week assessment being blinded. Diet, physical activity, and quality of life were measured with the Alternative Healthy Eating Index 2010, Stanford 7-Day Physical Activity Recall, and the EORTC Quality of life Questionnaire Core 30, respectively. We analyzed all eligible participants using the intention-to-treat approach in complete cases, adjusting for baseline values, body mass index, and age.</p> <p><strong>Results</strong> We enrolled 60 of the 296 potentially eligible endometrial cancer survivors (May - December 2015). Fifty-four eligible participants were randomized to the intervention (n=29) or usual care (n=31), and 49 had complete follow-up data (n=24 in the intervention and n= 25 in usual care). Intervention adherence was 77%. At 8 weeks, participants in the intervention improved their diet compared to usual care (difference in Alternative Healthy Eating Index 2010 score 7.5 (95% CI: 0.1 to 14.9), P=0.046) but not their physical activity (0.1 metabolic equivalent-h/day 95% CI: (-1.6 to 1.8), P=0.879), or global quality of life score (5.0 (95% CI: -3.4 to 13.3), P=0.236). Global quality of life improved in intervention participants at 24 weeks (difference 8.9 (95% CI: 0.9 to 16.8), P=0.029). No intervention-related adverse events were reported.</p> <p><strong>Conclusions</strong> The potential effectiveness of the intervention appeared promising. A future fully-powered study is needed to confirm these findings.</p> |
| first_indexed | 2024-03-06T21:24:40Z |
| format | Journal article |
| id | oxford-uuid:42abff75-2810-43eb-bfe1-8dd630a1f946 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:24:40Z |
| publishDate | 2019 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:42abff75-2810-43eb-bfe1-8dd630a1f9462022-03-26T14:50:54ZDiet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trialJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:42abff75-2810-43eb-bfe1-8dd630a1f946Symplectic Elements at OxfordBMJ Publishing Group2019Koutoukidis, DBeeken, RManchanda, RBurnell, MZiaudeen, NMichalopoulou, MKnobf, MLanceley, A<p><strong>Objectives</strong> To explore the effectiveness of a theory-based behavioral lifestyle intervention on health behaviors and quality of life in endometrial cancer survivors.’</p> <p><strong>Methods</strong> This was a secondary analysis of a randomized controlled pilot trial conducted in two UK hospitals enrolling disease-free stage I-IVA endometrial cancer survivors. Participants were allocated to an 8-week group-based healthy eating and physical activity intervention or usual care using 1:1 minimization. Participants were followed up at 8 and 24 weeks, with the 8-week assessment being blinded. Diet, physical activity, and quality of life were measured with the Alternative Healthy Eating Index 2010, Stanford 7-Day Physical Activity Recall, and the EORTC Quality of life Questionnaire Core 30, respectively. We analyzed all eligible participants using the intention-to-treat approach in complete cases, adjusting for baseline values, body mass index, and age.</p> <p><strong>Results</strong> We enrolled 60 of the 296 potentially eligible endometrial cancer survivors (May - December 2015). Fifty-four eligible participants were randomized to the intervention (n=29) or usual care (n=31), and 49 had complete follow-up data (n=24 in the intervention and n= 25 in usual care). Intervention adherence was 77%. At 8 weeks, participants in the intervention improved their diet compared to usual care (difference in Alternative Healthy Eating Index 2010 score 7.5 (95% CI: 0.1 to 14.9), P=0.046) but not their physical activity (0.1 metabolic equivalent-h/day 95% CI: (-1.6 to 1.8), P=0.879), or global quality of life score (5.0 (95% CI: -3.4 to 13.3), P=0.236). Global quality of life improved in intervention participants at 24 weeks (difference 8.9 (95% CI: 0.9 to 16.8), P=0.029). No intervention-related adverse events were reported.</p> <p><strong>Conclusions</strong> The potential effectiveness of the intervention appeared promising. A future fully-powered study is needed to confirm these findings.</p> |
| spellingShingle | Koutoukidis, D Beeken, R Manchanda, R Burnell, M Ziaudeen, N Michalopoulou, M Knobf, M Lanceley, A Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trial |
| title | Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trial |
| title_full | Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trial |
| title_fullStr | Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trial |
| title_full_unstemmed | Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trial |
| title_short | Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioral lifestyle program: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomized controlled pilot trial |
| title_sort | diet physical activity and health related outcomes of endometrial cancer survivors in a behavioral lifestyle program the diet and exercise in uterine cancer survivors deus parallel randomized controlled pilot trial |
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