Protocols to demonstrate slowing of Alzheimer disease progression - Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines
Two suggested clinical trial designs for assessing progression of Alzheimer disease are the randomized withdrawal design and the randomized start design. The most promising of these, the randomized start design, has the potential to demonstrate a delay in progression, but there remain problematic de...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
1997
|
| _version_ | 1826269421908262912 |
|---|---|
| author | Bodick, N Forette, F Hadler, D Harvey, R Leber, P McKeith, I Riekkinen, P Rossor, M Scheltens, P Shimohama, S Spiegel, R Tanaka, S Thal, L Urata, Y Whitehouse, P Wilcock, G |
| author_facet | Bodick, N Forette, F Hadler, D Harvey, R Leber, P McKeith, I Riekkinen, P Rossor, M Scheltens, P Shimohama, S Spiegel, R Tanaka, S Thal, L Urata, Y Whitehouse, P Wilcock, G |
| author_sort | Bodick, N |
| collection | OXFORD |
| description | Two suggested clinical trial designs for assessing progression of Alzheimer disease are the randomized withdrawal design and the randomized start design. The most promising of these, the randomized start design, has the potential to demonstrate a delay in progression, but there remain problematic design, ethical, and statistical issues to be solved before the protocol can be used in a clinical trial. The development of biological markers of the disease process using neuroimaging or other measures also may provide a robust method of measuring disease progression and demonstrating the biological effect of a drug on the disease process. © 1997 Lippincott-Raven Publishers. |
| first_indexed | 2024-03-06T21:24:48Z |
| format | Journal article |
| id | oxford-uuid:42b9fc7e-922c-455d-9e8c-d395fc9ecca6 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:24:48Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:42b9fc7e-922c-455d-9e8c-d395fc9ecca62022-03-26T14:51:12ZProtocols to demonstrate slowing of Alzheimer disease progression - Position paper from the International Working Group on Harmonization of Dementia Drug GuidelinesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:42b9fc7e-922c-455d-9e8c-d395fc9ecca6Symplectic Elements at Oxford1997Bodick, NForette, FHadler, DHarvey, RLeber, PMcKeith, IRiekkinen, PRossor, MScheltens, PShimohama, SSpiegel, RTanaka, SThal, LUrata, YWhitehouse, PWilcock, GTwo suggested clinical trial designs for assessing progression of Alzheimer disease are the randomized withdrawal design and the randomized start design. The most promising of these, the randomized start design, has the potential to demonstrate a delay in progression, but there remain problematic design, ethical, and statistical issues to be solved before the protocol can be used in a clinical trial. The development of biological markers of the disease process using neuroimaging or other measures also may provide a robust method of measuring disease progression and demonstrating the biological effect of a drug on the disease process. © 1997 Lippincott-Raven Publishers. |
| spellingShingle | Bodick, N Forette, F Hadler, D Harvey, R Leber, P McKeith, I Riekkinen, P Rossor, M Scheltens, P Shimohama, S Spiegel, R Tanaka, S Thal, L Urata, Y Whitehouse, P Wilcock, G Protocols to demonstrate slowing of Alzheimer disease progression - Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines |
| title | Protocols to demonstrate slowing of Alzheimer disease progression - Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines |
| title_full | Protocols to demonstrate slowing of Alzheimer disease progression - Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines |
| title_fullStr | Protocols to demonstrate slowing of Alzheimer disease progression - Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines |
| title_full_unstemmed | Protocols to demonstrate slowing of Alzheimer disease progression - Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines |
| title_short | Protocols to demonstrate slowing of Alzheimer disease progression - Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines |
| title_sort | protocols to demonstrate slowing of alzheimer disease progression position paper from the international working group on harmonization of dementia drug guidelines |
| work_keys_str_mv | AT bodickn protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT forettef protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT hadlerd protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT harveyr protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT leberp protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT mckeithi protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT riekkinenp protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT rossorm protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT scheltensp protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT shimohamas protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT spiegelr protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT tanakas protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT thall protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT uratay protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT whitehousep protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines AT wilcockg protocolstodemonstrateslowingofalzheimerdiseaseprogressionpositionpaperfromtheinternationalworkinggrouponharmonizationofdementiadrugguidelines |