A nucleotide-level coarse-grained model of RNA

We present a new, nucleotide-level model for RNA, oxRNA, based on the coarse-graining methodology recently developed for the oxDNA model of DNA. The model is designed to reproduce structural, mechanical, and thermodynamic properties of RNA, and the coarse-graining level aims to retain the relevant p...

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Main Authors: Šulc, P, Romano, F, Ouldridge, T, Doye, J, Louis, A
Formato: Journal article
Idioma:English
Publicado: American Institute of Physics 2014
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author Šulc, P
Romano, F
Ouldridge, T
Doye, J
Louis, A
author_facet Šulc, P
Romano, F
Ouldridge, T
Doye, J
Louis, A
author_sort Šulc, P
collection OXFORD
description We present a new, nucleotide-level model for RNA, oxRNA, based on the coarse-graining methodology recently developed for the oxDNA model of DNA. The model is designed to reproduce structural, mechanical, and thermodynamic properties of RNA, and the coarse-graining level aims to retain the relevant physics for RNA hybridization and the structure of single- and double-stranded RNA. In order to explore its strengths and weaknesses, we test the model in a range of nanotechnological and biological settings. Applications explored include the folding thermodynamics of a pseudoknot, the formation of a kissing loop complex, the structure of a hexagonal RNA nanoring, and the unzipping of a hairpin motif. We argue that the model can be used for efficient simulations of the structure of systems with thousands of base pairs, and for the assembly of systems of up to hundreds of base pairs. The source code implementing the model is released for public use.
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spelling oxford-uuid:42d0351a-1053-4fea-8764-b51a61aff7cd2022-03-26T14:51:42ZA nucleotide-level coarse-grained model of RNAJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:42d0351a-1053-4fea-8764-b51a61aff7cdEnglishSymplectic Elements at OxfordAmerican Institute of Physics2014Šulc, PRomano, FOuldridge, TDoye, JLouis, AWe present a new, nucleotide-level model for RNA, oxRNA, based on the coarse-graining methodology recently developed for the oxDNA model of DNA. The model is designed to reproduce structural, mechanical, and thermodynamic properties of RNA, and the coarse-graining level aims to retain the relevant physics for RNA hybridization and the structure of single- and double-stranded RNA. In order to explore its strengths and weaknesses, we test the model in a range of nanotechnological and biological settings. Applications explored include the folding thermodynamics of a pseudoknot, the formation of a kissing loop complex, the structure of a hexagonal RNA nanoring, and the unzipping of a hairpin motif. We argue that the model can be used for efficient simulations of the structure of systems with thousands of base pairs, and for the assembly of systems of up to hundreds of base pairs. The source code implementing the model is released for public use.
spellingShingle Šulc, P
Romano, F
Ouldridge, T
Doye, J
Louis, A
A nucleotide-level coarse-grained model of RNA
title A nucleotide-level coarse-grained model of RNA
title_full A nucleotide-level coarse-grained model of RNA
title_fullStr A nucleotide-level coarse-grained model of RNA
title_full_unstemmed A nucleotide-level coarse-grained model of RNA
title_short A nucleotide-level coarse-grained model of RNA
title_sort nucleotide level coarse grained model of rna
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