Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives.
An efficient nitro-Mannich/lactamization cascade of gamma-nitro esters with cyclic imines for the preparation of architecturally complex multicyclic piperidinone ring-containing structures has been developed. The reaction is broad in scope and stereoselective and may be coupled to an enantioselectiv...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797065191499759616 |
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| author | Jakubec, P Helliwell, M Dixon, D |
| author_facet | Jakubec, P Helliwell, M Dixon, D |
| author_sort | Jakubec, P |
| collection | OXFORD |
| description | An efficient nitro-Mannich/lactamization cascade of gamma-nitro esters with cyclic imines for the preparation of architecturally complex multicyclic piperidinone ring-containing structures has been developed. The reaction is broad in scope and stereoselective and may be coupled to an enantioselective nitroolefin Michael addition reaction as part of a highly enantio- and diastereoselective multicomponent process. |
| first_indexed | 2024-03-06T21:25:07Z |
| format | Journal article |
| id | oxford-uuid:42d262f0-ff89-431a-87fb-3ba37679ffff |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:25:07Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:42d262f0-ff89-431a-87fb-3ba37679ffff2022-03-26T14:51:42ZCyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:42d262f0-ff89-431a-87fb-3ba37679ffffEnglishSymplectic Elements at Oxford2008Jakubec, PHelliwell, MDixon, DAn efficient nitro-Mannich/lactamization cascade of gamma-nitro esters with cyclic imines for the preparation of architecturally complex multicyclic piperidinone ring-containing structures has been developed. The reaction is broad in scope and stereoselective and may be coupled to an enantioselective nitroolefin Michael addition reaction as part of a highly enantio- and diastereoselective multicomponent process. |
| spellingShingle | Jakubec, P Helliwell, M Dixon, D Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives. |
| title | Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives. |
| title_full | Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives. |
| title_fullStr | Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives. |
| title_full_unstemmed | Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives. |
| title_short | Cyclic imine nitro-Mannich/lactamization cascades: a direct stereoselective synthesis of multicyclic piperidinone derivatives. |
| title_sort | cyclic imine nitro mannich lactamization cascades a direct stereoselective synthesis of multicyclic piperidinone derivatives |
| work_keys_str_mv | AT jakubecp cycliciminenitromannichlactamizationcascadesadirectstereoselectivesynthesisofmulticyclicpiperidinonederivatives AT helliwellm cycliciminenitromannichlactamizationcascadesadirectstereoselectivesynthesisofmulticyclicpiperidinonederivatives AT dixond cycliciminenitromannichlactamizationcascadesadirectstereoselectivesynthesisofmulticyclicpiperidinonederivatives |