Impairment of invasion and maturation and decreased selectivity of Plasmodium falciparum in G6PD Viangchan and Mahidol variants
<p><i><strong>Background.</strong></i> Protection against <i>Plasmodium falciparum</i> is observed in a population deficient in glucose-6-phosphate dehydrogenase (G6PD), particularly in African and Mediterranean regions. However, such protection remains unkn...
| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2021
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| _version_ | 1826310384621977600 |
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| author | Palasuwan, D Palasuwan, A Boonpeng, K Ketprasit, N Imwong, M Kulkeaw, K |
| author_facet | Palasuwan, D Palasuwan, A Boonpeng, K Ketprasit, N Imwong, M Kulkeaw, K |
| author_sort | Palasuwan, D |
| collection | OXFORD |
| description | <p><i><strong>Background.</strong></i> Protection against <i>Plasmodium falciparum</i> is observed in a population deficient in glucose-6-phosphate dehydrogenase (G6PD), particularly in African and Mediterranean regions. However, such protection remains unknown among G6PD-deficient individuals in Southeast Asia.</p>
<p><i><strong>Methods.</strong></i> In this study, we assessed the invasion and maturation of <i>P falciparum</i> K1 in a culture of erythrocytes isolated from Thai subjects carrying Viangchan (871G > A) and Mahidol (487G > A).</p>
<p><i><strong>Results.</strong></i> We found that the parasites lost their ability to invade hemizygous and homozygous G6PD-deficient erythrocytes of Viangchan and Mahidol variants in the second and third cycles of intraerythrocytic development. It is interesting to note that <i>P falciparum</i> parasites selectively grew in erythrocytes from hemi- and homozygous genotypes with normal G6PD activity. Moreover, externalization of phosphatidylserine upon <i>P falciparum</i> infection was significantly increased only in Viangchan hemizygous variant cells.</p>
<p><i><strong>Conclusions.</strong></i> This study is the first to show that blockage of invasion in long-term culture and potentially enhanced removal of parasitized erythrocytes were observed for the first time in erythrocytes from Viangchan and Mahidol G6PD-deficient individuals.</p> |
| first_indexed | 2024-03-07T07:51:38Z |
| format | Journal article |
| id | oxford-uuid:42dfcc0f-3caf-4d0e-bc3d-1a99a0048460 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:51:38Z |
| publishDate | 2021 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:42dfcc0f-3caf-4d0e-bc3d-1a99a00484602023-07-19T10:43:49ZImpairment of invasion and maturation and decreased selectivity of Plasmodium falciparum in G6PD Viangchan and Mahidol variantsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:42dfcc0f-3caf-4d0e-bc3d-1a99a0048460EnglishSymplectic ElementsOxford University Press2021Palasuwan, DPalasuwan, ABoonpeng, KKetprasit, NImwong, MKulkeaw, K<p><i><strong>Background.</strong></i> Protection against <i>Plasmodium falciparum</i> is observed in a population deficient in glucose-6-phosphate dehydrogenase (G6PD), particularly in African and Mediterranean regions. However, such protection remains unknown among G6PD-deficient individuals in Southeast Asia.</p> <p><i><strong>Methods.</strong></i> In this study, we assessed the invasion and maturation of <i>P falciparum</i> K1 in a culture of erythrocytes isolated from Thai subjects carrying Viangchan (871G > A) and Mahidol (487G > A).</p> <p><i><strong>Results.</strong></i> We found that the parasites lost their ability to invade hemizygous and homozygous G6PD-deficient erythrocytes of Viangchan and Mahidol variants in the second and third cycles of intraerythrocytic development. It is interesting to note that <i>P falciparum</i> parasites selectively grew in erythrocytes from hemi- and homozygous genotypes with normal G6PD activity. Moreover, externalization of phosphatidylserine upon <i>P falciparum</i> infection was significantly increased only in Viangchan hemizygous variant cells.</p> <p><i><strong>Conclusions.</strong></i> This study is the first to show that blockage of invasion in long-term culture and potentially enhanced removal of parasitized erythrocytes were observed for the first time in erythrocytes from Viangchan and Mahidol G6PD-deficient individuals.</p> |
| spellingShingle | Palasuwan, D Palasuwan, A Boonpeng, K Ketprasit, N Imwong, M Kulkeaw, K Impairment of invasion and maturation and decreased selectivity of Plasmodium falciparum in G6PD Viangchan and Mahidol variants |
| title | Impairment of invasion and maturation and decreased selectivity of Plasmodium falciparum in G6PD Viangchan and Mahidol variants |
| title_full | Impairment of invasion and maturation and decreased selectivity of Plasmodium falciparum in G6PD Viangchan and Mahidol variants |
| title_fullStr | Impairment of invasion and maturation and decreased selectivity of Plasmodium falciparum in G6PD Viangchan and Mahidol variants |
| title_full_unstemmed | Impairment of invasion and maturation and decreased selectivity of Plasmodium falciparum in G6PD Viangchan and Mahidol variants |
| title_short | Impairment of invasion and maturation and decreased selectivity of Plasmodium falciparum in G6PD Viangchan and Mahidol variants |
| title_sort | impairment of invasion and maturation and decreased selectivity of plasmodium falciparum in g6pd viangchan and mahidol variants |
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