FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

Compartmentalized cAMP/PKA signalling is now recognized as important for physiology and pathophysiology, yet a detailed understanding of the properties, regulation and function of local cAMP/PKA signals is lacking. Here we present a fluorescence resonance energy transfer (FRET)-based sensor, CUTie,...

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Bibliographic Details
Main Authors:	Surdo, N, Berrera, M, Koschinski, A, Brescia, M, Machado, M, Carr, C, Wright, P, Gorelik, J, Morotti, S, Grandi, E, Bers, D, Pantano, S, Zaccolo, M
Format:	Journal article
Published:	Springer Nature 2017

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