The synthesis and biological evaluation of PROTACs targeting the transcriptional coactivators CREBBP and p300
<p>CREBBP and p300 are multidomain paralogues involved in numerous cellular pathways, including epigenetic regulation and the mediation of target gene expression. They share high sequence and structure homologies and perform distinct, but overlapping, cellular functions. Mutations in both CREB...
Main Author: | Andrews, KH |
---|---|
Other Authors: | Conway, S |
Format: | Thesis |
Language: | English |
Published: |
2023
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Subjects: |
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