Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man?
Small doses (1-10 microgram daily) of 24,25-dihydroxycholecalciferol (24,25-(OH)2D3), a renal metabolite of vitamin D of uncertain function, increased intestinal absorption of calcium in normal people and in patients with various disorders or mineral metabolism, including anephric subjects. In five...
| Үндсэн зохиолчид: | , , , , , , |
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| Формат: | Journal article |
| Хэл сонгох: | English |
| Хэвлэсэн: |
1978
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| _version_ | 1826269459226034176 |
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| author | Kanis, J Cundy, T Bartlett, M Smith, R Heynen, G Warner, G Russell, R |
| author_facet | Kanis, J Cundy, T Bartlett, M Smith, R Heynen, G Warner, G Russell, R |
| author_sort | Kanis, J |
| collection | OXFORD |
| description | Small doses (1-10 microgram daily) of 24,25-dihydroxycholecalciferol (24,25-(OH)2D3), a renal metabolite of vitamin D of uncertain function, increased intestinal absorption of calcium in normal people and in patients with various disorders or mineral metabolism, including anephric subjects. In five of six patients studied, calcium balance increased, but, unlike 1,25-dihydroxycholecalciferol, 24,25-(OH)2D3 did not increase plasma or urinary calcium concentrations. These results suggest that 24,25-(OH)2D3 may be an important regulator of skeletal metabolism in man with potential value as a therapeutic agent. |
| first_indexed | 2024-03-06T21:25:23Z |
| format | Journal article |
| id | oxford-uuid:42ed2f9b-2f63-4109-a56c-c868af4baecc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:25:23Z |
| publishDate | 1978 |
| record_format | dspace |
| spelling | oxford-uuid:42ed2f9b-2f63-4109-a56c-c868af4baecc2022-03-26T14:52:14ZIs 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:42ed2f9b-2f63-4109-a56c-c868af4baeccEnglishSymplectic Elements at Oxford1978Kanis, JCundy, TBartlett, MSmith, RHeynen, GWarner, GRussell, RSmall doses (1-10 microgram daily) of 24,25-dihydroxycholecalciferol (24,25-(OH)2D3), a renal metabolite of vitamin D of uncertain function, increased intestinal absorption of calcium in normal people and in patients with various disorders or mineral metabolism, including anephric subjects. In five of six patients studied, calcium balance increased, but, unlike 1,25-dihydroxycholecalciferol, 24,25-(OH)2D3 did not increase plasma or urinary calcium concentrations. These results suggest that 24,25-(OH)2D3 may be an important regulator of skeletal metabolism in man with potential value as a therapeutic agent. |
| spellingShingle | Kanis, J Cundy, T Bartlett, M Smith, R Heynen, G Warner, G Russell, R Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man? |
| title | Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man? |
| title_full | Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man? |
| title_fullStr | Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man? |
| title_full_unstemmed | Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man? |
| title_short | Is 24,25-dihydroxycholecalciferol a calcium-regulating hormone in man? |
| title_sort | is 24 25 dihydroxycholecalciferol a calcium regulating hormone in man |
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