Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.

Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.

Compartmentalization of the BCR in membrane rafts is important for its signaling capacity. Swiprosin-1/EFhd2 (Swip-1) is an EF-hand and coiled-coil-containing adaptor protein with predicted Src homology 3 (SH3) binding sites that we identified in membrane rafts. We showed previously that Swip-1 ampl...

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Detalles Bibliográficos
Main Authors: Kroczek, C, Lang, C, Brachs, S, Grohmann, M, Dütting, S, Schweizer, A, Nitschke, L, Feller, S, Jäck, H, Mielenz, D
Formato: Journal article
Idioma:English
Publicado: 2010

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