Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.

Swiprosin-1/EFhd2 controls B cell receptor signaling through the assembly of the B cell receptor, Syk, and phospholipase C gamma2 in membrane rafts.

Compartmentalization of the BCR in membrane rafts is important for its signaling capacity. Swiprosin-1/EFhd2 (Swip-1) is an EF-hand and coiled-coil-containing adaptor protein with predicted Src homology 3 (SH3) binding sites that we identified in membrane rafts. We showed previously that Swip-1 ampl...

書目詳細資料
Main Authors:	Kroczek, C, Lang, C, Brachs, S, Grohmann, M, Dütting, S, Schweizer, A, Nitschke, L, Feller, S, Jäck, H, Mielenz, D
格式:	Journal article
語言:	English
出版:	2010

相似書籍

Swiprosin 1 – regulator of proximal BCR signaling
由: Mielenz D, et al.
出版: (2009-02-01)

B Cell Speed and B-FDC Contacts in Germinal Centers Determine Plasma Cell Output via Swiprosin-1/EFhd2
由: Dorothea Reimer, et al.
出版: (2020-08-01)

The Ca2+ sensor protein swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons.
由: Pavitra Purohit, et al.
出版: (2014-01-01)

Structural and Biochemical Characterization of EFhd1/Swiprosin-2, an Actin-Binding Protein in Mitochondria
由: Sang A. Mun, et al.
出版: (2021-01-01)

Role of Syk in B-cell development and antigen-receptor signaling.
由: Cornall, R, et al.
出版: (2000)

B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk
由: Kathrin Kläsener, et al.
出版: (2014-06-01)

Structural and biochemical insights into Zn2+-bound EF-hand proteins, EFhd1 and EFhd2
由: Sang A Mun, et al.
出版: (2023-03-01)

Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases
由: Mukherjee, Sayak, et al.
出版: (2014)

Dual BTK/SYK inhibition with CG-806 (luxeptinib) disrupts B-cell receptor and Bcl-2 signaling networks in mantle cell lymphoma
由: Elana Thieme, et al.
出版: (2022-03-01)

SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia
由: Cody Paiva, et al.
出版: (2017-11-01)

Are rafts involved in T-cell receptor signalling? Introduction to the Talking Point on the involvement of lipid rafts in T-cell activation.
由: de Wet, B, et al.
出版: (2008)

EFhd2 co-aggregates with monomeric and filamentous tau in vitro
由: Ahlam S. Soliman, et al.
出版: (2024-05-01)

EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death
由: Jiacheng Wu, et al.
出版: (2024-02-01)

Human dendritic cell maturation induced by amorphous silica nanoparticles is Syk-dependent and triggered by lipid raft aggregation
由: Éléonore Guillet, et al.
出版: (2023-04-01)

Mercury alters endogenous phosphorylation profiles of SYK in murine B cells
由: Joseph A. Caruso, et al.
出版: (2017-07-01)

Expression of Phospholipase A2 Receptor in Pediatric Hepatitis B Virus-Related Membranous Nephropathy
由: Sung-Eun Choi, et al.
出版: (2020-04-01)

Lipid raft domains and protein networks in T-cell receptor signal transduction.
由: Harder, T
出版: (2004)

Lipid raft domains and protein networks in T-cell receptor signal transduction
由: Harder, T
出版: (2004)

Lipid Rafts Interaction of the ARID3A Transcription Factor with EZRIN and G-Actin Regulates B-Cell Receptor Signaling
由: Christian Schmidt, et al.
出版: (2021-03-01)

PCSK9 stimulates Syk, PKCδ, and NF-κB, leading to atherosclerosis progression independently of LDL receptor
由: Dasom Shin, et al.
出版: (2024-03-01)

Modulation of BCR Signaling by the Induced Dimerization of Receptor-Associated SYK
由: Mark L. Westbroek, et al.
出版: (2017-12-01)

Entry of Francisella tularensis into Murine B Cells: The Role of B Cell Receptors and Complement Receptors.
由: Lenka Plzakova, et al.
出版: (2015-01-01)

T-cell receptor and B-cell receptor repertoires profiling in pleural tuberculosis
由: Fengjiao Du, et al.
出版: (2024-11-01)

Erythropoietin receptor signaling is membrane raft dependent.
由: Kathy L McGraw, et al.
出版: (2012-01-01)

<i>Stephania tetrandra</i> and Its Active Compound Coclaurine Sensitize NSCLC Cells to Cisplatin through EFHD2 Inhibition
由: Shu-Yu Hu, et al.
出版: (2024-10-01)

The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens.
由: Bachmann, M, et al.
出版: (1999)

Regulation of B cell functions by the sialic acid-binding receptors Siglec-G and CD22
由: Julia eJellusova, et al.
出版: (2012-01-01)

Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells
由: Akira Abe, et al.
出版: (2004-04-01)

Tau’s Three-Repeat Domain and EFhd2 Co-incubation Leads to Increased Thioflavin Signal
由: Irving E. Vega, et al.
出版: (2018-12-01)

HSL-knockout mouse testis exhibits class B scavenger receptor upregulation and disrupted lipid raft microdomains[S]
由: María Emilia Casado, et al.
出版: (2012-12-01)

Phase I study of the Syk inhibitor sovleplenib in relapsed or refractory mature B-cell tumors
由: Yuqin Song, et al.
出版: (2024-01-01)

EFHD2 contributes to non-small cell lung cancer cisplatin resistance by the activation of NOX4-ROS-ABCC1 axis
由: Chi-Chen Fan, et al.
出版: (2020-07-01)

Anti-phospholipase A2 receptor antibodies in membranous nephropathy
由: Sangho Lee
出版: (2018-09-01)

The shape of the lymphocyte receptor repertoire: lessons from the B cell receptor
由: Katherine J. L. Jackson, et al.
出版: (2013-09-01)

EFHD1 expression is correlated with tumor-infiltrating neutrophils and predicts prognosis in gastric cancer
由: Bin Zhao, et al.
出版: (2023-10-01)

Aberrant methylation of the M-type phospholipase A<sub>2</sub> receptor gene in leukemic cells
由: Menschikowski Mario, et al.
出版: (2012-12-01)

Phospholipase D4 as a signature of toll-like receptor 7 or 9 signaling is expressed on blastic T-bet + B cells in systemic lupus erythematosus
由: Ken Yasaka, et al.
出版: (2023-10-01)

Characterisation of the mechanism of B-cell receptor triggering
由: Wilcock, M
出版: (2018)

Hypercholesterolemia Correlates With Glomerular Phospholipase A2 Receptor Deposit and Serum Anti-Phospholipase A2 Receptor Antibody and Predicts Proteinuria Outcome in Idiopathic Membranous Nephropathy
由: Lei Dong, et al.
出版: (2022-06-01)

On thermalization in the SYK and supersymmetric SYK models
由: Nicholas Hunter-Jones, et al.
出版: (2018-02-01)