CD39 Expression identifies terminally exhausted CD8+ T cells

CD39 Expression identifies terminally exhausted CD8+ T cells

Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. Defining novel markers of exhaustion is important both for identifying and potentially reversing T cell exhaustion. Herein, we show that the ectonucleotidse CD39 is a...

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Bibliographic Details
Main Authors: Gupta, P, Godec, J, Wolski, D, Adland, E, Yates, K, Pauken, K, Cosgrove, C, Ledderose, C, Junger, W, Robson, S, Wherry, E, Alter, G, Goulder, P, Klenerman, P, Sharpe, A, Lauer, G, Haining, W
Format: Journal article
Language:English
Published: Public Library of Science 2015

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