Development of anti-TNF therapy for rheumatoid arthritis.
The aetiology of systemic, autoimmune, chronic inflammatory diseases--such as rheumatoid arthritis--is not known, and their pathogenesis is complex and multifactorial. However, progress in the characterization of intercellular mediators--proteins that are now known as cytokines--has led to the reali...
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1826269518662467584 |
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| author | Feldmann, M |
| author_facet | Feldmann, M |
| author_sort | Feldmann, M |
| collection | OXFORD |
| description | The aetiology of systemic, autoimmune, chronic inflammatory diseases--such as rheumatoid arthritis--is not known, and their pathogenesis is complex and multifactorial. However, progress in the characterization of intercellular mediators--proteins that are now known as cytokines--has led to the realization that one cytokine, tumour-necrosis factor (TNF; previously known as TNF-alpha), has an important role in the pathogenesis of rheumatoid arthritis. This discovery heralded a new era of targeted and highly effective therapeutics for rheumatoid arthritis and, subsequently, other chronic inflammatory diseases. |
| first_indexed | 2024-03-06T21:26:19Z |
| format | Journal article |
| id | oxford-uuid:4334f6df-ea11-44dc-9f80-1cbd93fee41a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:26:19Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:4334f6df-ea11-44dc-9f80-1cbd93fee41a2022-03-26T14:54:04ZDevelopment of anti-TNF therapy for rheumatoid arthritis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4334f6df-ea11-44dc-9f80-1cbd93fee41aEnglishSymplectic Elements at Oxford2002Feldmann, MThe aetiology of systemic, autoimmune, chronic inflammatory diseases--such as rheumatoid arthritis--is not known, and their pathogenesis is complex and multifactorial. However, progress in the characterization of intercellular mediators--proteins that are now known as cytokines--has led to the realization that one cytokine, tumour-necrosis factor (TNF; previously known as TNF-alpha), has an important role in the pathogenesis of rheumatoid arthritis. This discovery heralded a new era of targeted and highly effective therapeutics for rheumatoid arthritis and, subsequently, other chronic inflammatory diseases. |
| spellingShingle | Feldmann, M Development of anti-TNF therapy for rheumatoid arthritis. |
| title | Development of anti-TNF therapy for rheumatoid arthritis. |
| title_full | Development of anti-TNF therapy for rheumatoid arthritis. |
| title_fullStr | Development of anti-TNF therapy for rheumatoid arthritis. |
| title_full_unstemmed | Development of anti-TNF therapy for rheumatoid arthritis. |
| title_short | Development of anti-TNF therapy for rheumatoid arthritis. |
| title_sort | development of anti tnf therapy for rheumatoid arthritis |
| work_keys_str_mv | AT feldmannm developmentofantitnftherapyforrheumatoidarthritis |