Functional consequences of pre- and postsynaptic expression of synaptic plasticity
Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of...
| Glavni autori: | , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
Royal Society
2017
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| _version_ | 1826269524180074496 |
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| author | Costa, R Mizusaki, B Sjöström, P van Rossum, M |
| author_facet | Costa, R Mizusaki, B Sjöström, P van Rossum, M |
| author_sort | Costa, R |
| collection | OXFORD |
| description | Growing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'. |
| first_indexed | 2024-03-06T21:26:24Z |
| format | Journal article |
| id | oxford-uuid:433b9a18-21da-4363-8a0b-26f655f2baa1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:26:24Z |
| publishDate | 2017 |
| publisher | Royal Society |
| record_format | dspace |
| spelling | oxford-uuid:433b9a18-21da-4363-8a0b-26f655f2baa12022-03-26T14:54:11ZFunctional consequences of pre- and postsynaptic expression of synaptic plasticityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:433b9a18-21da-4363-8a0b-26f655f2baa1EnglishSymplectic Elements at OxfordRoyal Society2017Costa, RMizusaki, BSjöström, Pvan Rossum, MGrowing experimental evidence shows that both homeostatic and Hebbian synaptic plasticity can be expressed presynaptically as well as postsynaptically. In this review, we start by discussing this evidence and methods used to determine expression loci. Next, we discuss the functional consequences of this diversity in pre- and postsynaptic expression of both homeostatic and Hebbian synaptic plasticity. In particular, we explore the functional consequences of a biologically tuned model of pre- and postsynaptically expressed spike-timing-dependent plasticity complemented with postsynaptic homeostatic control. The pre- and postsynaptic expression in this model predicts (i) more reliable receptive fields and sensory perception, (ii) rapid recovery of forgotten information (memory savings), and (iii) reduced response latencies, compared with a model with postsynaptic expression only. Finally, we discuss open questions that will require a considerable research effort to better elucidate how the specific locus of expression of homeostatic and Hebbian plasticity alters synaptic and network computations.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'. |
| spellingShingle | Costa, R Mizusaki, B Sjöström, P van Rossum, M Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title | Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title_full | Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title_fullStr | Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title_full_unstemmed | Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title_short | Functional consequences of pre- and postsynaptic expression of synaptic plasticity |
| title_sort | functional consequences of pre and postsynaptic expression of synaptic plasticity |
| work_keys_str_mv | AT costar functionalconsequencesofpreandpostsynapticexpressionofsynapticplasticity AT mizusakib functionalconsequencesofpreandpostsynapticexpressionofsynapticplasticity AT sjostromp functionalconsequencesofpreandpostsynapticexpressionofsynapticplasticity AT vanrossumm functionalconsequencesofpreandpostsynapticexpressionofsynapticplasticity |