Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence.
We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic phot...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Publishing Group
2014
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| _version_ | 1826269532068511744 |
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| author | McNamara, C Tejero-Cantero, A Trouche, S Campo-Urriza, N Dupret, D |
| author_facet | McNamara, C Tejero-Cantero, A Trouche, S Campo-Urriza, N Dupret, D |
| author_sort | McNamara, C |
| collection | OXFORD |
| description | We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence. |
| first_indexed | 2024-03-06T21:26:31Z |
| format | Journal article |
| id | oxford-uuid:4344bf18-94bc-4acf-95a5-0d4b8135a498 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:26:31Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:4344bf18-94bc-4acf-95a5-0d4b8135a4982022-03-26T14:54:25ZDopaminergic neurons promote hippocampal reactivation and spatial memory persistence.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4344bf18-94bc-4acf-95a5-0d4b8135a498EnglishSymplectic Elements at OxfordNature Publishing Group2014McNamara, CTejero-Cantero, ATrouche, SCampo-Urriza, NDupret, DWe found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improved the later recall of neural representations of space and stabilized memory performance. These findings reveal that midbrain dopaminergic neurons promote hippocampal network dynamics associated with memory persistence. |
| spellingShingle | McNamara, C Tejero-Cantero, A Trouche, S Campo-Urriza, N Dupret, D Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence. |
| title | Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence. |
| title_full | Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence. |
| title_fullStr | Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence. |
| title_full_unstemmed | Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence. |
| title_short | Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence. |
| title_sort | dopaminergic neurons promote hippocampal reactivation and spatial memory persistence |
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