Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
<p><strong>Background and purpose</strong> Previous studies, mostly focusing on the European population, have reported polygenic risk scores (PRSs) might achieve risk stratification of stroke. We aimed to examine the association strengths of PRSs with risks of stroke and its subtyp...
| Main Authors: | , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
| Published: |
BMJ Publishing Group
2023
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| _version_ | 1826315220893564928 |
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| author | Yang, S Sun, Z Sun, D Yang, L Millwood, IY Walters, RG Chen, Y Du, H Burgess, S Avery, D Clarke, R Chen, Z |
| author2 | China Kadoorie Biobank Collaborative Group |
| author_facet | China Kadoorie Biobank Collaborative Group Yang, S Sun, Z Sun, D Yang, L Millwood, IY Walters, RG Chen, Y Du, H Burgess, S Avery, D Clarke, R Chen, Z |
| author_sort | Yang, S |
| collection | OXFORD |
| description | <p><strong>Background and purpose</strong> Previous studies, mostly focusing on the European population, have reported polygenic risk scores (PRSs) might achieve risk stratification of stroke. We aimed to examine the association strengths of PRSs with risks of stroke and its subtypes in the Chinese population.</p>
<p><strong>Methods</strong> Participants with genome-wide genotypic data in China Kadoorie Biobank were split into a potential training set (n=22 191) and a population-based testing set (n=72 150). Four previously developed PRSs were included, and new PRSs for stroke and its subtypes were developed. The PRSs showing the strongest association with risks of stroke or its subtypes in the training set were further evaluated in the testing set. Cox proportional hazards regression models were used to estimate the association strengths of different PRSs with risks of stroke and its subtypes (ischaemic stroke (IS), intracerebral haemorrhage (ICH) and subarachnoid haemorrhage (SAH)).</p>
<p><strong>Results</strong> In the testing set, during 872 919 person-years of follow-up, 8514 incident stroke events were documented. The PRSs of any stroke (AS) and IS were both positively associated with risks of AS, IS and ICH (p<0.05). The HR for per SD increment (HR<sub>SD</sub>) of PRS<sub>AS</sub> was 1.10 (95% CI 1.07 to 1.12), 1.10 (95% CI 1.07 to 1.12) and 1.13 (95% CI 1.07 to 1.20) for AS, IS and ICH, respectively. The corresponding HR<sub>SD</sub> of PRS<sub>IS</sub> was 1.08 (95% CI 1.06 to 1.11), 1.08 (95% CI 1.06 to 1.11) and 1.09 (95% CI 1.03 to 1.15). PRS<sub>ICH</sub> was positively associated with the risk of ICH (HR<sub>SD</sub>=1.07, 95% CI 1.01 to 1.14). PRS<sub>SAH</sub> was not associated with risks of stroke and its subtypes. The addition of current PRSs offered little to no improvement in stroke risk prediction and risk stratification.</p>
<p><strong>Conclusions</strong> In this Chinese population, the association strengths of current PRSs with risks of stroke and its subtypes were moderate, suggesting a limited value for improving risk prediction over traditional risk factors in the context of current genome-wide association study under-representing the East Asian population.</p> |
| first_indexed | 2024-03-07T08:03:22Z |
| format | Journal article |
| id | oxford-uuid:4350817e-b520-4db7-a898-55c854c5580b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-12-09T03:21:07Z |
| publishDate | 2023 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:4350817e-b520-4db7-a898-55c854c5580b2024-11-13T10:13:46ZAssociations of polygenic risk scores with risks of stroke and its subtypes in ChineseJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4350817e-b520-4db7-a898-55c854c5580bEnglishSymplectic ElementsBMJ Publishing Group2023Yang, SSun, ZSun, DYang, LMillwood, IYWalters, RGChen, YDu, HBurgess, SAvery, DClarke, RChen, ZChina Kadoorie Biobank Collaborative Group<p><strong>Background and purpose</strong> Previous studies, mostly focusing on the European population, have reported polygenic risk scores (PRSs) might achieve risk stratification of stroke. We aimed to examine the association strengths of PRSs with risks of stroke and its subtypes in the Chinese population.</p> <p><strong>Methods</strong> Participants with genome-wide genotypic data in China Kadoorie Biobank were split into a potential training set (n=22 191) and a population-based testing set (n=72 150). Four previously developed PRSs were included, and new PRSs for stroke and its subtypes were developed. The PRSs showing the strongest association with risks of stroke or its subtypes in the training set were further evaluated in the testing set. Cox proportional hazards regression models were used to estimate the association strengths of different PRSs with risks of stroke and its subtypes (ischaemic stroke (IS), intracerebral haemorrhage (ICH) and subarachnoid haemorrhage (SAH)).</p> <p><strong>Results</strong> In the testing set, during 872 919 person-years of follow-up, 8514 incident stroke events were documented. The PRSs of any stroke (AS) and IS were both positively associated with risks of AS, IS and ICH (p<0.05). The HR for per SD increment (HR<sub>SD</sub>) of PRS<sub>AS</sub> was 1.10 (95% CI 1.07 to 1.12), 1.10 (95% CI 1.07 to 1.12) and 1.13 (95% CI 1.07 to 1.20) for AS, IS and ICH, respectively. The corresponding HR<sub>SD</sub> of PRS<sub>IS</sub> was 1.08 (95% CI 1.06 to 1.11), 1.08 (95% CI 1.06 to 1.11) and 1.09 (95% CI 1.03 to 1.15). PRS<sub>ICH</sub> was positively associated with the risk of ICH (HR<sub>SD</sub>=1.07, 95% CI 1.01 to 1.14). PRS<sub>SAH</sub> was not associated with risks of stroke and its subtypes. The addition of current PRSs offered little to no improvement in stroke risk prediction and risk stratification.</p> <p><strong>Conclusions</strong> In this Chinese population, the association strengths of current PRSs with risks of stroke and its subtypes were moderate, suggesting a limited value for improving risk prediction over traditional risk factors in the context of current genome-wide association study under-representing the East Asian population.</p> |
| spellingShingle | Yang, S Sun, Z Sun, D Yang, L Millwood, IY Walters, RG Chen, Y Du, H Burgess, S Avery, D Clarke, R Chen, Z Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese |
| title | Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese |
| title_full | Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese |
| title_fullStr | Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese |
| title_full_unstemmed | Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese |
| title_short | Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese |
| title_sort | associations of polygenic risk scores with risks of stroke and its subtypes in chinese |
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