Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.

Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides a step toward the aim of knocking out all genes and screening each line for a broad range of traits. We found that h...

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Bibliographic Details
Main Authors: White, J, Gerdin, A, Karp, N, Ryder, E, Buljan, M, Bussell, J, Salisbury, J, Clare, S, Ingham, N, Podrini, C, Houghton, R, Estabel, J, Bottomley, JR, Melvin, D, Sunter, D, Adams, N, Tannahill, D, Logan, D, Macarthur, D, Flint, J, Mahajan, V, Tsang, S, Smyth, I, Watt, F, Skarnes, W
Format: Journal article
Language:English
Published: 2013

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