Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock.
Modulation of central 5-HT receptor sensitivity is implicated in the therapeutic response to electroconvulsive shock (ECS). Altered 5-HT receptor expression may play a role in this process. We have measured the mRNAs encoding 5-HT1A, 5-HT2A, 5-HT2C and 5-HT7 receptors, and the 5-HT transporter, in r...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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1999
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| _version_ | 1826269564693905408 |
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| author | Burnet, P Sharp, T LeCorre, S Harrison, P |
| author_facet | Burnet, P Sharp, T LeCorre, S Harrison, P |
| author_sort | Burnet, P |
| collection | OXFORD |
| description | Modulation of central 5-HT receptor sensitivity is implicated in the therapeutic response to electroconvulsive shock (ECS). Altered 5-HT receptor expression may play a role in this process. We have measured the mRNAs encoding 5-HT1A, 5-HT2A, 5-HT2C and 5-HT7 receptors, and the 5-HT transporter, in rat brain after single ECS, repeated ECS, and 3 weeks after repeated ECS. Hippocampal 5-HT1A receptor mRNA was decreased in CA4 and increased in dentate gyrus by single or repeated ECS, with parallel alterations in [3H]8-OH-DPAT binding site densities. Repeated ECS increased cortical [3H]ketanserin binding and 5-HT2A receptor mRNA. The other mRNAs were unchanged. The results show that ECS has subtype specific, anatomically discrete, and temporally selective effects on 5-HT receptor expression. |
| first_indexed | 2024-03-06T21:27:03Z |
| format | Journal article |
| id | oxford-uuid:4374984c-d3a4-4970-8bc7-3ad14a07ff50 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:27:03Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:4374984c-d3a4-4970-8bc7-3ad14a07ff502022-03-26T14:55:25ZExpression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4374984c-d3a4-4970-8bc7-3ad14a07ff50EnglishSymplectic Elements at Oxford1999Burnet, PSharp, TLeCorre, SHarrison, PModulation of central 5-HT receptor sensitivity is implicated in the therapeutic response to electroconvulsive shock (ECS). Altered 5-HT receptor expression may play a role in this process. We have measured the mRNAs encoding 5-HT1A, 5-HT2A, 5-HT2C and 5-HT7 receptors, and the 5-HT transporter, in rat brain after single ECS, repeated ECS, and 3 weeks after repeated ECS. Hippocampal 5-HT1A receptor mRNA was decreased in CA4 and increased in dentate gyrus by single or repeated ECS, with parallel alterations in [3H]8-OH-DPAT binding site densities. Repeated ECS increased cortical [3H]ketanserin binding and 5-HT2A receptor mRNA. The other mRNAs were unchanged. The results show that ECS has subtype specific, anatomically discrete, and temporally selective effects on 5-HT receptor expression. |
| spellingShingle | Burnet, P Sharp, T LeCorre, S Harrison, P Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock. |
| title | Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock. |
| title_full | Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock. |
| title_fullStr | Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock. |
| title_full_unstemmed | Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock. |
| title_short | Expression of 5-HT receptors and the 5-HT transporter in rat brain after electroconvulsive shock. |
| title_sort | expression of 5 ht receptors and the 5 ht transporter in rat brain after electroconvulsive shock |
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