Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury.

Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury.

Autoimmune neuropathies are frequently associated with pathogenic anti-ganglioside antibodies targeting ganglioside-rich neuronal and glial membranes. The extent of injury is determined by the concentration of membrane ganglioside and thus reduction might be expected to attenuate disease. In this st...

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Bibliografiske detaljer
Main Authors:	Townson, K, Speak, A, Greenshields, K, Goodyear, C, Willison, H, Platt, F
Format:	Journal article
Sprog:	English
Udgivet:	2008

Lignende værker

Ganglioside antibodies and neuropathies.
af: Rinaldi, S, et al.
Udgivet: (2008)

Multi-system disorders of glycosphingolipid and ganglioside metabolism
af: You-Hai Xu, et al.
Udgivet: (2010-07-01)

Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.
af: Elisa Lombardo, et al.
Udgivet: (2012-01-01)

Characterization and quantitative determination of gangliosides and neutral glycosphingolipids in human liver.
af: O Nilsson, et al.
Udgivet: (1982-02-01)

Glycosphingolipids in endocytic membrane transport.
af: Sillence, D, et al.
Udgivet: (2004)

Generalized accumulation of neutral glycosphingolipids with GM2 ganglioside accumulation in the brain
af: Paul D. Snyder, Jr., et al.
Udgivet: (1972-01-01)

A rapid and quantitative method for the isolation of gangliosides and neutral glycosphingolipids by DEAE-silica gel chromatography.
af: S K Kundu, et al.
Udgivet: (1978-03-01)

Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease.
af: Karen M Ashe, et al.
Udgivet: (2011-01-01)

Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.
af: Pei, B, et al.
Udgivet: (2011)

New GM1 Ganglioside Derivatives for Selective Single and Double Labelling of the Natural Glycosphingolipid Skeleton
af: Polyakova, S, et al.
Udgivet: (2009)

Iminosugar inhibitors for treating the lysosomal glycosphingolipidoses
af: Butters, T, et al.
Udgivet: (2005)

Introduction: Glycosphingolipids in cell biology and disease.
af: Sillence, D, et al.
Udgivet: (2004)

Glycosphingolipid antigens from Leishmania (L.) amazonensis amastigotes: Binding of anti-glycosphingolipid monoclonal antibodies in vitro and in vivo
af: A.H. Straus, et al.
Udgivet: (1997-03-01)

[Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function].
af: Porubsky, S, et al.
Udgivet: (2008)

Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function
af: Porubsky, S, et al.
Udgivet: (2008)

Substrate reduction therapy for glycosphingolipid storage disorders.
af: Lachmann, R, et al.
Udgivet: (2001)

A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue)
af: Kelly L. Warfield, et al.
Udgivet: (2015-05-01)

Regulation of membrane-bound enzymes of glycosphingolipid biosynthesis
af: J D Burczak, et al.
Udgivet: (1984-12-01)

Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides
af: Pan, X, et al.
Udgivet: (2017)

Glycosphingolipid dysregulation and lysosomal dysfunction in motor neuron disease
af: da Silva Santos, CS
Udgivet: (2021)

Glycosphingolipid lysosomal storage diseases: therapy and pathogenesis.
af: Jeyakumar, M, et al.
Udgivet: (2002)

Anti-ganglioside antibodies and celiac disease
af: Alessandro Granito, et al.
Udgivet: (2021-05-01)

The relationship between depletion of brain GM1 ganglioside and Parkinson's disease
af: Sandro Sonnino
Udgivet: (2023-09-01)

New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases.
af: Butters, T, et al.
Udgivet: (2003)

Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders.
af: Butters, T, et al.
Udgivet: (2000)

New developments in treating glycosphingolipid storage diseases.
af: Platt, F, et al.
Udgivet: (2005)

Iminosugar for treatment of tumors
af: Dwek, R, et al.
Udgivet: (2008)

Glycosphingolipid metabolism and its role in ageing and Parkinson’s disease
af: Wallom, K-L, et al.
Udgivet: (2021)

Altered expression of ganglioside metabolizing enzymes results in GM3 ganglioside accumulation in cerebellar cells of a mouse model of juvenile neuronal ceroid lipofuscinosis
af: Somogyi, A, et al.
Udgivet: (2018)

Ultrasound-mediated piezoelectric differentiation of neuron-like PC12 cells on PVDF membranes
af: Marcus Hoop, et al.
Udgivet: (2017-06-01)

Iminosugar antivirals: the therapeutic sweet spot
af: Alonzi, D, et al.
Udgivet: (2017)

Identification of GM1-Ganglioside Secondary Accumulation in Fibroblasts from Neuropathic Gaucher Patients and Effect of a Trivalent Trihydroxypiperidine Iminosugar Compound on Its Storage Reduction
af: Costanza Ceni, et al.
Udgivet: (2024-01-01)

Iminosugars: promising therapeutics for influenza infection
af: Tyrrell, B, et al.
Udgivet: (2016)

Profile in ganglioside antibodies in benign prostatic hyperplasia
af: Ilinca Nicolae, et al.
Udgivet: (2016-03-01)

ALTERED AUTOPHAGY AND APP METABOLISM IN GLYCOSPHINGOLIPID STORAGE DISEASES
af: Boland, B, et al.
Udgivet: (2011)

The mechanism of action of iminosugars as antiretrovirals
af: Spiro, S, et al.
Udgivet: (2014)

The synthesis and biology of iminosugars and their precursors
af: Ayers, B, et al.
Udgivet: (2014)

The synthesis of branched sugars and iminosugars
af: Parry, LL
Udgivet: (2011)

Total asymmetric syntheses of iminosugars
af: Figuccia, A, et al.
Udgivet: (2015)

Substrate deprivation: a new therapeutic approach for the glycosphingolipid lysosomal storage diseases.
af: Platt, F, et al.
Udgivet: (2000)