Two antioxidants are better than one.
New evidence suggests that the cellular oxygen-sensing hypoxia-inducible factor(HIF) pathway may be protected by a double buffer of cellular antioxidant defense. Key players in the oxygen-dependent regulation of this pathway are the prolyl hydroxylase domain-containing enzymes (PHDs) that catalyze t...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797065354155917312 |
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| author | Lappin, T Masson, N |
| author_facet | Lappin, T Masson, N |
| author_sort | Lappin, T |
| collection | OXFORD |
| description | New evidence suggests that the cellular oxygen-sensing hypoxia-inducible factor(HIF) pathway may be protected by a double buffer of cellular antioxidant defense. Key players in the oxygen-dependent regulation of this pathway are the prolyl hydroxylase domain-containing enzymes (PHDs) that catalyze the prolyl-4-hydroxylation of HIFα, dependent on the presence of oxygen, 2-oxoglutarate, and iron in the ferrous (Fe(2+)) form. Vitamin C is also required as a cofactor, possibly to maintain the catalytic iron center in its functional Fe(2+)) state, although both the mechanism and the in vivo requirement are not absolutely clear. |
| first_indexed | 2024-03-06T21:27:27Z |
| format | Journal article |
| id | oxford-uuid:4392b904-97a9-48d6-b7be-a17b109982f4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:27:27Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:4392b904-97a9-48d6-b7be-a17b109982f42022-03-26T14:56:17ZTwo antioxidants are better than one.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4392b904-97a9-48d6-b7be-a17b109982f4EnglishSymplectic Elements at Oxford2011Lappin, TMasson, NNew evidence suggests that the cellular oxygen-sensing hypoxia-inducible factor(HIF) pathway may be protected by a double buffer of cellular antioxidant defense. Key players in the oxygen-dependent regulation of this pathway are the prolyl hydroxylase domain-containing enzymes (PHDs) that catalyze the prolyl-4-hydroxylation of HIFα, dependent on the presence of oxygen, 2-oxoglutarate, and iron in the ferrous (Fe(2+)) form. Vitamin C is also required as a cofactor, possibly to maintain the catalytic iron center in its functional Fe(2+)) state, although both the mechanism and the in vivo requirement are not absolutely clear. |
| spellingShingle | Lappin, T Masson, N Two antioxidants are better than one. |
| title | Two antioxidants are better than one. |
| title_full | Two antioxidants are better than one. |
| title_fullStr | Two antioxidants are better than one. |
| title_full_unstemmed | Two antioxidants are better than one. |
| title_short | Two antioxidants are better than one. |
| title_sort | two antioxidants are better than one |
| work_keys_str_mv | AT lappint twoantioxidantsarebetterthanone AT massonn twoantioxidantsarebetterthanone |