Serum bactericidal and inhibitory titres in the management of melioidosis.
A retrospective evaluation of the relationship between serum bactericidal and inhibitory titres and treatment outcome in 195 adult Thai patients with severe melioidosis was conducted. Drug regimens included ceftazidime (52% of patients), co-amoxiclav (24%), imipenem (11%) or the conventional four-dr...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2000
|
| _version_ | 1797065356064325632 |
|---|---|
| author | Simpson, A Dance, D Wuthiekanun, V White, N |
| author_facet | Simpson, A Dance, D Wuthiekanun, V White, N |
| author_sort | Simpson, A |
| collection | OXFORD |
| description | A retrospective evaluation of the relationship between serum bactericidal and inhibitory titres and treatment outcome in 195 adult Thai patients with severe melioidosis was conducted. Drug regimens included ceftazidime (52% of patients), co-amoxiclav (24%), imipenem (11%) or the conventional four-drug combination (11%). Pre- and 1 h post-dose serum samples were collected after 48-72 h of therapy, and serum inhibitory and bactericidal titrations determined. Median post-dose titres were: bactericidal 1:8 (range 0-1:128) and inhibitory 1:16 (range 0-1:128). Overall mortality was 26% and outcome was not influenced by either inhibitory or bactericidal titres. Pre-dose titres correlated with renal function; renal function was the most important predictor of mortality. Determination of serum inhibitory or bactericidal titres is unhelpful in the management of severe melioidosis. |
| first_indexed | 2024-03-06T21:27:29Z |
| format | Journal article |
| id | oxford-uuid:4394abce-ba6c-494a-ae71-434d835d697f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:27:29Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:4394abce-ba6c-494a-ae71-434d835d697f2022-03-26T14:56:25ZSerum bactericidal and inhibitory titres in the management of melioidosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4394abce-ba6c-494a-ae71-434d835d697fEnglishSymplectic Elements at Oxford2000Simpson, ADance, DWuthiekanun, VWhite, NA retrospective evaluation of the relationship between serum bactericidal and inhibitory titres and treatment outcome in 195 adult Thai patients with severe melioidosis was conducted. Drug regimens included ceftazidime (52% of patients), co-amoxiclav (24%), imipenem (11%) or the conventional four-drug combination (11%). Pre- and 1 h post-dose serum samples were collected after 48-72 h of therapy, and serum inhibitory and bactericidal titrations determined. Median post-dose titres were: bactericidal 1:8 (range 0-1:128) and inhibitory 1:16 (range 0-1:128). Overall mortality was 26% and outcome was not influenced by either inhibitory or bactericidal titres. Pre-dose titres correlated with renal function; renal function was the most important predictor of mortality. Determination of serum inhibitory or bactericidal titres is unhelpful in the management of severe melioidosis. |
| spellingShingle | Simpson, A Dance, D Wuthiekanun, V White, N Serum bactericidal and inhibitory titres in the management of melioidosis. |
| title | Serum bactericidal and inhibitory titres in the management of melioidosis. |
| title_full | Serum bactericidal and inhibitory titres in the management of melioidosis. |
| title_fullStr | Serum bactericidal and inhibitory titres in the management of melioidosis. |
| title_full_unstemmed | Serum bactericidal and inhibitory titres in the management of melioidosis. |
| title_short | Serum bactericidal and inhibitory titres in the management of melioidosis. |
| title_sort | serum bactericidal and inhibitory titres in the management of melioidosis |
| work_keys_str_mv | AT simpsona serumbactericidalandinhibitorytitresinthemanagementofmelioidosis AT danced serumbactericidalandinhibitorytitresinthemanagementofmelioidosis AT wuthiekanunv serumbactericidalandinhibitorytitresinthemanagementofmelioidosis AT whiten serumbactericidalandinhibitorytitresinthemanagementofmelioidosis |