IgM in human immunity to Plasmodium falciparum malaria
Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM ac...
| Asıl Yazarlar: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
American Association for the Advancement of Science
2019
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| _version_ | 1826269595911061504 |
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| author | Boyle, MJ Chan, JA Handayuni, I Reiling, L Feng, G Hilton, G Kurtovic, L Oyong, O Piera, KA Barber, BE William, T Eisen, DP Minigo, G Langer, C Drew, DR de Labastida Rivera, F Amante, FH Williams, TN Kinyanjui, S Marsh, K Doolan, DL Engwerda, C Fowkes, FJI Grigg, MJ Mueller, I McCarthy, JS Anstey, NM Beeson, JG |
| author_facet | Boyle, MJ Chan, JA Handayuni, I Reiling, L Feng, G Hilton, G Kurtovic, L Oyong, O Piera, KA Barber, BE William, T Eisen, DP Minigo, G Langer, C Drew, DR de Labastida Rivera, F Amante, FH Williams, TN Kinyanjui, S Marsh, K Doolan, DL Engwerda, C Fowkes, FJI Grigg, MJ Mueller, I McCarthy, JS Anstey, NM Beeson, JG |
| author_sort | Boyle, MJ |
| collection | OXFORD |
| description | Most studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM activity against blood-stage parasites. We found that merozoite-specific IgM appears rapidly in Plasmodium falciparum infection and is prominent during malaria in children and adults with lifetime exposure, together with IgG. Unexpectedly, IgM persisted for extended periods of time; we found no difference in decay of merozoite-specific IgM over time compared to that of IgG. IgM blocked merozoite invasion of red blood cells in a complement-dependent manner. IgM was also associated with significantly reduced risk of clinical malaria in a longitudinal cohort of children. These findings suggest that merozoite-specific IgM is an important functional and long-lived antibody response targeting blood-stage malaria parasites that contributes to malaria immunity. |
| first_indexed | 2024-03-06T21:27:32Z |
| format | Journal article |
| id | oxford-uuid:439931cb-d4d3-4c84-ad5c-d2d5d6e29971 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:27:32Z |
| publishDate | 2019 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:439931cb-d4d3-4c84-ad5c-d2d5d6e299712022-03-26T14:56:28ZIgM in human immunity to Plasmodium falciparum malariaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:439931cb-d4d3-4c84-ad5c-d2d5d6e29971EnglishSymplectic ElementsAmerican Association for the Advancement of Science2019Boyle, MJChan, JAHandayuni, IReiling, LFeng, GHilton, GKurtovic, LOyong, OPiera, KABarber, BEWilliam, TEisen, DPMinigo, GLanger, CDrew, DRde Labastida Rivera, FAmante, FHWilliams, TNKinyanjui, SMarsh, KDoolan, DLEngwerda, CFowkes, FJIGrigg, MJMueller, IMcCarthy, JSAnstey, NMBeeson, JGMost studies on human immunity to malaria have focused on the roles of immunoglobulin G (IgG), whereas the roles of IgM remain undefined. Analyzing multiple human cohorts to assess the dynamics of malaria-specific IgM during experimentally induced and naturally acquired malaria, we identified IgM activity against blood-stage parasites. We found that merozoite-specific IgM appears rapidly in Plasmodium falciparum infection and is prominent during malaria in children and adults with lifetime exposure, together with IgG. Unexpectedly, IgM persisted for extended periods of time; we found no difference in decay of merozoite-specific IgM over time compared to that of IgG. IgM blocked merozoite invasion of red blood cells in a complement-dependent manner. IgM was also associated with significantly reduced risk of clinical malaria in a longitudinal cohort of children. These findings suggest that merozoite-specific IgM is an important functional and long-lived antibody response targeting blood-stage malaria parasites that contributes to malaria immunity. |
| spellingShingle | Boyle, MJ Chan, JA Handayuni, I Reiling, L Feng, G Hilton, G Kurtovic, L Oyong, O Piera, KA Barber, BE William, T Eisen, DP Minigo, G Langer, C Drew, DR de Labastida Rivera, F Amante, FH Williams, TN Kinyanjui, S Marsh, K Doolan, DL Engwerda, C Fowkes, FJI Grigg, MJ Mueller, I McCarthy, JS Anstey, NM Beeson, JG IgM in human immunity to Plasmodium falciparum malaria |
| title | IgM in human immunity to Plasmodium falciparum malaria |
| title_full | IgM in human immunity to Plasmodium falciparum malaria |
| title_fullStr | IgM in human immunity to Plasmodium falciparum malaria |
| title_full_unstemmed | IgM in human immunity to Plasmodium falciparum malaria |
| title_short | IgM in human immunity to Plasmodium falciparum malaria |
| title_sort | igm in human immunity to plasmodium falciparum malaria |
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