Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice
The extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse partitioning, to detect gene by sex (GxS) and gene by gene (GxG) quantitative loci (QTLs) in 1,900 outbred heterogeneous stock mice. In an analysis of 55...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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Public Library of Science
2014
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| _version_ | 1826269596502458368 |
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| author | Krohn, J Speed, D Palme, R Touma, C Mott, R Flint, J |
| author_facet | Krohn, J Speed, D Palme, R Touma, C Mott, R Flint, J |
| author_sort | Krohn, J |
| collection | OXFORD |
| description | The extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse partitioning, to detect gene by sex (GxS) and gene by gene (GxG) quantitative loci (QTLs) in 1,900 outbred heterogeneous stock mice. In an analysis of 55 phenotypes, we detected 16 GxS and 6 GxG QTLs. The increase in the amount of phenotypic variance explained by models including GxS was small, ranging from 0.14% to 4.30%. We conclude that GxS rarely make a large overall contribution to the heritability of phenotypes, however there are cases where these will be individually important. |
| first_indexed | 2024-03-06T21:27:33Z |
| format | Journal article |
| id | oxford-uuid:439a0aaf-a66a-4442-8afd-835e2bdd8066 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:27:33Z |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:439a0aaf-a66a-4442-8afd-835e2bdd80662022-03-26T14:56:33ZGenetic interactions with sex make a relatively small contribution to the heritability of complex traits in miceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:439a0aaf-a66a-4442-8afd-835e2bdd8066EnglishSymplectic Elements at OxfordPublic Library of Science2014Krohn, JSpeed, DPalme, RTouma, CMott, RFlint, JThe extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse partitioning, to detect gene by sex (GxS) and gene by gene (GxG) quantitative loci (QTLs) in 1,900 outbred heterogeneous stock mice. In an analysis of 55 phenotypes, we detected 16 GxS and 6 GxG QTLs. The increase in the amount of phenotypic variance explained by models including GxS was small, ranging from 0.14% to 4.30%. We conclude that GxS rarely make a large overall contribution to the heritability of phenotypes, however there are cases where these will be individually important. |
| spellingShingle | Krohn, J Speed, D Palme, R Touma, C Mott, R Flint, J Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice |
| title | Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice |
| title_full | Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice |
| title_fullStr | Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice |
| title_full_unstemmed | Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice |
| title_short | Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice |
| title_sort | genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice |
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