Standardized methods for enhanced quality and comparability of tuberculous meningitis studies
Tuberculous meningitis remains a major cause of death and disability in tuberculosis endemic areas, especially in young children and immunocompromised adults. Research aimed at improving outcomes is hampered by poor standardization, which limits study comparison and the generalizability of results....
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
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Oxford University Press
2016
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| _version_ | 1826269610430693376 |
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| author | Marais, B Heemskerk, A Marais, S van Crevel, R Rohlwink, U Caws, M Meintjes, G Misra, U Mai, N Ruslami, R Seddon, J Solomons, R van Toorn, R Figaji, A McIlleron, H Aarnoutse, R Schoeman, J Wilkinson, R Thwaites, G |
| author_facet | Marais, B Heemskerk, A Marais, S van Crevel, R Rohlwink, U Caws, M Meintjes, G Misra, U Mai, N Ruslami, R Seddon, J Solomons, R van Toorn, R Figaji, A McIlleron, H Aarnoutse, R Schoeman, J Wilkinson, R Thwaites, G |
| author_sort | Marais, B |
| collection | OXFORD |
| description | Tuberculous meningitis remains a major cause of death and disability in tuberculosis endemic areas, especially in young children and immunocompromised adults. Research aimed at improving outcomes is hampered by poor standardization, which limits study comparison and the generalizability of results. We propose standardized methods for the conduct of tuberculous meningitis clinical research that were drafted at an international tuberculous meningitis research meeting organized by the Oxford University Clinical Research Unit in Vietnam. We propose a core dataset including demographic and clinical information to be collected at study enrolment, important aspects related to patient management and monitoring, and standardized reporting of patient outcomes. The criteria proposed for the conduct of observational and intervention tuberculous meningitis studies should improve the quality of future research outputs, facilitate multi-centre studies and meta-analyses of pooled data, and could provide the foundation for a global tuberculous meningitis data repository. |
| first_indexed | 2024-03-06T21:27:46Z |
| format | Journal article |
| id | oxford-uuid:43aa2099-63af-4593-9495-70d70a48c4e8 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:27:46Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:43aa2099-63af-4593-9495-70d70a48c4e82022-03-26T14:56:53ZStandardized methods for enhanced quality and comparability of tuberculous meningitis studiesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:43aa2099-63af-4593-9495-70d70a48c4e8Symplectic Elements at OxfordOxford University Press2016Marais, BHeemskerk, AMarais, Svan Crevel, RRohlwink, UCaws, MMeintjes, GMisra, UMai, NRuslami, RSeddon, JSolomons, Rvan Toorn, RFigaji, AMcIlleron, HAarnoutse, RSchoeman, JWilkinson, RThwaites, GTuberculous meningitis remains a major cause of death and disability in tuberculosis endemic areas, especially in young children and immunocompromised adults. Research aimed at improving outcomes is hampered by poor standardization, which limits study comparison and the generalizability of results. We propose standardized methods for the conduct of tuberculous meningitis clinical research that were drafted at an international tuberculous meningitis research meeting organized by the Oxford University Clinical Research Unit in Vietnam. We propose a core dataset including demographic and clinical information to be collected at study enrolment, important aspects related to patient management and monitoring, and standardized reporting of patient outcomes. The criteria proposed for the conduct of observational and intervention tuberculous meningitis studies should improve the quality of future research outputs, facilitate multi-centre studies and meta-analyses of pooled data, and could provide the foundation for a global tuberculous meningitis data repository. |
| spellingShingle | Marais, B Heemskerk, A Marais, S van Crevel, R Rohlwink, U Caws, M Meintjes, G Misra, U Mai, N Ruslami, R Seddon, J Solomons, R van Toorn, R Figaji, A McIlleron, H Aarnoutse, R Schoeman, J Wilkinson, R Thwaites, G Standardized methods for enhanced quality and comparability of tuberculous meningitis studies |
| title | Standardized methods for enhanced quality and comparability of tuberculous meningitis studies |
| title_full | Standardized methods for enhanced quality and comparability of tuberculous meningitis studies |
| title_fullStr | Standardized methods for enhanced quality and comparability of tuberculous meningitis studies |
| title_full_unstemmed | Standardized methods for enhanced quality and comparability of tuberculous meningitis studies |
| title_short | Standardized methods for enhanced quality and comparability of tuberculous meningitis studies |
| title_sort | standardized methods for enhanced quality and comparability of tuberculous meningitis studies |
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