Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis

Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis

An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched β-substituted ketone products w...

Detaylı Bibliyografya
Asıl Yazarlar:	Cheang, DMJ, Armstrong, RJ, Akhtar, WM, Donohoe, TJ
Materyal Türü:	Journal article
Dil:	English
Baskı/Yayın Bilgisi:	Royal Society of Chemistry 2020

Benzer Materyaller

The α-alkylation of ketones using hydrogen borrowing catalysis
Yazar:: Akhtar, W
Baskı/Yayın Bilgisi: (2018)

Stereoselective synthesis of alicyclic ketones: a hydrogen borrowing approach
Yazar:: Armstrong, RJ, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

Controlling absolute stereochemistry in hydrogen borrowing catalysed alkylation
Yazar:: Cheang, DMJ-Y
Baskı/Yayın Bilgisi: (2023)

Enantioconvergent catalysis
Yazar:: Justin T. Mohr, ve diğerleri
Baskı/Yayın Bilgisi: (2016-09-01)

Dynamic kinetic resolution allows control of remote stereochemistry in asymmetric hydrogen borrowing alkylation
Yazar:: Cheang, DMJ, ve diğerleri
Baskı/Yayın Bilgisi: (2025)

Hydrogen borrowing catalysis using 1° and 2° alcohols: investigation and scope leading to α and β branched products
Yazar:: Frost, JR, ve diğerleri
Baskı/Yayın Bilgisi: (2021)

Strategic application and transformation of ortho-disubstituted phenyl and cyclopropyl ketones to expand the scope of hydrogen borrowing catalysis.
Yazar:: Frost, J, ve diğerleri
Baskı/Yayın Bilgisi: (2015)

Functional group tolerant hydrogen borrowing C-alkylation
Yazar:: Bailey, EP, ve diğerleri
Baskı/Yayın Bilgisi: (2024)

Functional group tolerant hydrogen borrowing C-alkylation
Yazar:: Bailey, EP, ve diğerleri
Baskı/Yayın Bilgisi: (2024)

Enantioconvergent Cross-Couplings of Racemic Alkylmetal Reagents with Unactivated Secondary Alkyl Electrophiles: Catalytic Asymmetric Negishi α-Alkylations of N-Boc-Pyrrolidine
Yazar:: Cordier, Christopher J., ve diğerleri
Baskı/Yayın Bilgisi: (2018)

The iridium-catalysed alkylation of aromatic ketones via hydrogen borrowing
Yazar:: Cheong, C
Baskı/Yayın Bilgisi: (2018)

Hydrogen borrowing catalysis with secondary alcohols: a new route for the generation of β-branched carbonyl compounds
Yazar:: Akhtar, W, ve diğerleri
Baskı/Yayın Bilgisi: (2017)

Hydrogen-Borrowing and Interrupted-Hydrogen-Borrowing Reactions of Ketones and Methanol Catalyzed by Iridium.
Yazar:: Shen, D, ve diğerleri
Baskı/Yayın Bilgisi: (2014)

Hydrogen-borrowing and interrupted-hydrogen-borrowing reactions of ketones and methanol catalyzed by iridium
Yazar:: Shen, D, ve diğerleri
Baskı/Yayın Bilgisi: (2015)

Iridium-catalyzed C4-alkylation of 2,6-di-tert-butylphenol by using hydrogen-borrowing catalysis
Yazar:: Frost, J, ve diğerleri
Baskı/Yayın Bilgisi: (2016)

Heterogeneous Mn@CeO2 Catalyst for α‑Alkylation of Ketones with Alcohols via Hydrogen-Borrowing Strategy
Yazar:: Rajagopal Swaathy, ve diğerleri
Baskı/Yayın Bilgisi: (2025-02-01)

Extension of hydrogen borrowing alkylation reactions for the total synthesis of (–)-γ-lycorane
Yazar:: Hall, C, ve diğerleri
Baskı/Yayın Bilgisi: (2022)

Control of absolute stereochemistry in transition-metal-catalyzed hydrogen borrowing reactions
Yazar:: Kwok, T, ve diğerleri
Baskı/Yayın Bilgisi: (2020)

Hydrogen-Borrowing Alkylation of 1,2-Amino Alcohols in the Synthesis of Enantioenriched γ-Aminobutyric Acids
Yazar:: Hall, CJJ, ve diğerleri
Baskı/Yayın Bilgisi: (2021)

Functional group tolerant hydrogen borrowing C-alkylation
Yazar:: Elliot P. Bailey, ve diğerleri
Baskı/Yayın Bilgisi: (2024-06-01)

Ni-catalyzed enantioconvergent deoxygenative reductive cross-coupling of unactivated alkyl alcohols and aryl bromides
Yazar:: Li-Li Zhang, ve diğerleri
Baskı/Yayın Bilgisi: (2024-03-01)

Ligand‐Promoted [Pd]‐Catalyzed α‐Alkylation of Ketones through a Borrowing‐Hydrogen Approach
Yazar:: Dr. Seetharaman Manojveer, ve diğerleri
Baskı/Yayın Bilgisi: (2023-01-01)

Enantioconvergent nucleophilic substitution via synergistic phase-transfer catalysis
Yazar:: Dooley, C, ve diğerleri
Baskı/Yayın Bilgisi: (2025)

Ligand-enabled Ni-catalysed enantioconvergent intermolecular Alkyl-Alkyl cross-coupling between distinct Alkyl halides
Yazar:: Wen-Tao Zhao, ve diğerleri
Baskı/Yayın Bilgisi: (2023-05-01)

Enantioconvergent construction of stereogenic silicon via Lewis base-catalyzed dynamic kinetic silyletherification of racemic chlorosilanes
Yazar:: Tianbao Hu, ve diğerleri
Baskı/Yayın Bilgisi: (2023-08-01)

Catalytic asymmetric synthesis of cyclohexanes by hydrogen borrowing annulations
Yazar:: Armstrong, R, ve diğerleri
Baskı/Yayın Bilgisi: (2019)

Formal enantioconvergent substitution of alkyl halides via catalytic asymmetric photoredox radical coupling
Yazar:: Jiangtao Li, ve diğerleri
Baskı/Yayın Bilgisi: (2018-06-01)

Enantioconvergent halogenophilic nucleophilic substitution (SN2X) reaction by chiral phase-transfer catalysis
Yazar:: Zhang, Xin
Baskı/Yayın Bilgisi: (2019)

Cyclometalated Iridium Complex-Catalyzed N‑Alkylation of Amines with Alcohols via Borrowing Hydrogen in Aqueous Media
Yazar:: NianHua Luo, ve diğerleri
Baskı/Yayın Bilgisi: (2020-10-01)

Pentamethylphenyl (Ph*) ketones: Unique building blocks for organic synthesis
Yazar:: Armstrong, R, ve diğerleri
Baskı/Yayın Bilgisi: (2021)

Asymmetric Alkyl−Alkyl Cross-Couplings of Unactivated Secondary Alkyl Electrophiles: Stereoconvergent Suzuki Reactions of Racemic Acylated Halohydrins
Yazar:: Owston, Nathan A., ve diğerleri
Baskı/Yayın Bilgisi: (2013)

Recent developments in transition metal-catalyzed asymmetric borrowing hydrogen catalysis
Yazar:: Nidhi Garg, ve diğerleri
Baskı/Yayın Bilgisi: (2023-12-01)

A vinyl cyclopropane ring expansion and iridium‐catalyzed hydrogen borrowing cascade
Yazar:: Wübbolt, S, ve diğerleri
Baskı/Yayın Bilgisi: (2020)

A vinyl cyclopropane ring expansion and iridium‐catalyzed hydrogen borrowing cascade
Yazar:: Wubbolt, S, ve diğerleri
Baskı/Yayın Bilgisi: (2020)

The Allylic Alkylation of Ketone Enolates
Yazar:: Dr. Lukas Junk, ve diğerleri
Baskı/Yayın Bilgisi: (2020-09-01)

Hydrogen borrowing-based methods for the construction of quaternary stereocentres
Yazar:: Crompton, J, ve diğerleri
Baskı/Yayın Bilgisi: (2025)

Development of functional group tolerant and room temperature hydrogen borrowing enolate alkylation reactions
Yazar:: Bailey, EP
Baskı/Yayın Bilgisi: (2023)

Asymmetric α-C(sp 3)−H allylic alkylation of primary alkylamines by synergistic Ir/ketone catalysis
Yazar:: Jianyu Li, ve diğerleri
Baskı/Yayın Bilgisi: (2024-01-01)

Parallel kinetic resolution of racemic ketones through reduction: a quantitative analysis
Yazar:: Juan R. Dehli, ve diğerleri
Baskı/Yayın Bilgisi: (2002-06-01)

Asymmetric Suzuki Cross-Couplings of Activated Secondary Alkyl Electrophiles: Arylations of Racemic α-Chloroamides
Yazar:: Lundin, Pamela M., ve diğerleri
Baskı/Yayın Bilgisi: (2013)