IFITM3: how genetics influence influenza infection demographically
The role of host genetics in influenza infection is unclear despite decades of interest. Confounding factors such as age, sex, ethnicity and environmental factors have made it difficult to assess the role of genetics without influence. In recent years a single nucleotide polymorphism, interferon-ind...
| Main Authors: | , , , |
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| Format: | Journal article |
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Elsevier
2019
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| _version_ | 1797065380394434560 |
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| author | Wellington, D Laurenson-Schafer, H Abdel-Haq, A Dong, T |
| author_facet | Wellington, D Laurenson-Schafer, H Abdel-Haq, A Dong, T |
| author_sort | Wellington, D |
| collection | OXFORD |
| description | The role of host genetics in influenza infection is unclear despite decades of interest. Confounding factors such as age, sex, ethnicity and environmental factors have made it difficult to assess the role of genetics without influence. In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations. In this review we investigate this polymorphism as well as several others suggested to alter the host's defence against influenza infection. In addition, we highlight the open questions surrounding the viral restriction protein IFITM3 with the hope that by answering some of these questions we can elucidate the mechanism of IFITM3 viral restriction and therefore how this restriction is altered due to the rs12252 polymorphism. |
| first_indexed | 2024-03-06T21:27:50Z |
| format | Journal article |
| id | oxford-uuid:43b0626a-057a-4e61-bb68-103415e057e6 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:27:50Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:43b0626a-057a-4e61-bb68-103415e057e62022-03-26T14:56:58ZIFITM3: how genetics influence influenza infection demographicallyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:43b0626a-057a-4e61-bb68-103415e057e6Symplectic Elements at OxfordElsevier2019Wellington, DLaurenson-Schafer, HAbdel-Haq, ADong, TThe role of host genetics in influenza infection is unclear despite decades of interest. Confounding factors such as age, sex, ethnicity and environmental factors have made it difficult to assess the role of genetics without influence. In recent years a single nucleotide polymorphism, interferon-induced transmembrane protein 3 (IFITM3) rs12252, has been shown to alter the severity of influenza infection in Asian populations. In this review we investigate this polymorphism as well as several others suggested to alter the host's defence against influenza infection. In addition, we highlight the open questions surrounding the viral restriction protein IFITM3 with the hope that by answering some of these questions we can elucidate the mechanism of IFITM3 viral restriction and therefore how this restriction is altered due to the rs12252 polymorphism. |
| spellingShingle | Wellington, D Laurenson-Schafer, H Abdel-Haq, A Dong, T IFITM3: how genetics influence influenza infection demographically |
| title | IFITM3: how genetics influence influenza infection demographically |
| title_full | IFITM3: how genetics influence influenza infection demographically |
| title_fullStr | IFITM3: how genetics influence influenza infection demographically |
| title_full_unstemmed | IFITM3: how genetics influence influenza infection demographically |
| title_short | IFITM3: how genetics influence influenza infection demographically |
| title_sort | ifitm3 how genetics influence influenza infection demographically |
| work_keys_str_mv | AT wellingtond ifitm3howgeneticsinfluenceinfluenzainfectiondemographically AT laurensonschaferh ifitm3howgeneticsinfluenceinfluenzainfectiondemographically AT abdelhaqa ifitm3howgeneticsinfluenceinfluenzainfectiondemographically AT dongt ifitm3howgeneticsinfluenceinfluenzainfectiondemographically |