Correlation of tolerogenicity of a viral antigen with its immunogenicity.
Induction of B cell tolerance or activation was analyzed with vesicular stomatitis virus (VSV) glycoprotein (G) expressed as a neo-self Ag. A membrane form of VSV-G expressed in all tissues, including the bone marrow, induced unresponsiveness at both the Th and B cell level, whereas a soluble form o...
| Главные авторы: | , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
1997
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| _version_ | 1826269629693034496 |
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| author | Bachmann, M Fehr, T Freer, G Hengartner, H Zinkernagel, R |
| author_facet | Bachmann, M Fehr, T Freer, G Hengartner, H Zinkernagel, R |
| author_sort | Bachmann, M |
| collection | OXFORD |
| description | Induction of B cell tolerance or activation was analyzed with vesicular stomatitis virus (VSV) glycoprotein (G) expressed as a neo-self Ag. A membrane form of VSV-G expressed in all tissues, including the bone marrow, induced unresponsiveness at both the Th and B cell level, whereas a soluble form of VSV-G expressed peripherally in liver and kidney did not tolerize B cells and only reversibly anergized Th cells. Interestingly, a similar correlation was found for activation of mature lymphocytes. When mature normal spleen cells were transferred into the two transgenic mouse lines, the membrane form of VSV-G was strongly immunogenic for both Th and B cells, and high VSV-G-specific IgG Ab titers were induced in these transgenic mice. In contrast, spleen cells transferred into mice expressing the soluble form of VSV-G were not activated, and no VSV-G specific Abs were induced. These results indicate that highly immunogenic Ags are strongly tolerogenic for both immature B and T cells. |
| first_indexed | 2024-03-06T21:28:04Z |
| format | Journal article |
| id | oxford-uuid:43c28f85-3fd0-4b40-9d08-b74cfa0261b8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:28:04Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:43c28f85-3fd0-4b40-9d08-b74cfa0261b82022-03-26T14:57:21ZCorrelation of tolerogenicity of a viral antigen with its immunogenicity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:43c28f85-3fd0-4b40-9d08-b74cfa0261b8EnglishSymplectic Elements at Oxford1997Bachmann, MFehr, TFreer, GHengartner, HZinkernagel, RInduction of B cell tolerance or activation was analyzed with vesicular stomatitis virus (VSV) glycoprotein (G) expressed as a neo-self Ag. A membrane form of VSV-G expressed in all tissues, including the bone marrow, induced unresponsiveness at both the Th and B cell level, whereas a soluble form of VSV-G expressed peripherally in liver and kidney did not tolerize B cells and only reversibly anergized Th cells. Interestingly, a similar correlation was found for activation of mature lymphocytes. When mature normal spleen cells were transferred into the two transgenic mouse lines, the membrane form of VSV-G was strongly immunogenic for both Th and B cells, and high VSV-G-specific IgG Ab titers were induced in these transgenic mice. In contrast, spleen cells transferred into mice expressing the soluble form of VSV-G were not activated, and no VSV-G specific Abs were induced. These results indicate that highly immunogenic Ags are strongly tolerogenic for both immature B and T cells. |
| spellingShingle | Bachmann, M Fehr, T Freer, G Hengartner, H Zinkernagel, R Correlation of tolerogenicity of a viral antigen with its immunogenicity. |
| title | Correlation of tolerogenicity of a viral antigen with its immunogenicity. |
| title_full | Correlation of tolerogenicity of a viral antigen with its immunogenicity. |
| title_fullStr | Correlation of tolerogenicity of a viral antigen with its immunogenicity. |
| title_full_unstemmed | Correlation of tolerogenicity of a viral antigen with its immunogenicity. |
| title_short | Correlation of tolerogenicity of a viral antigen with its immunogenicity. |
| title_sort | correlation of tolerogenicity of a viral antigen with its immunogenicity |
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