T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.
The LMO2 gene is involved in T-cell acute leukaemia (T-ALL) in children with chromosomal translocations t(11;14)(p13;q11) or (7;11)(q35;p13). Transgenic expression of Lmo2 in T cells results in clonal tumours with long latency indicating that mutations in other genes are required for the development...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2001
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| _version_ | 1797065408354713600 |
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| author | Drynan, L Hamilton, T Rabbitts, T |
| author_facet | Drynan, L Hamilton, T Rabbitts, T |
| author_sort | Drynan, L |
| collection | OXFORD |
| description | The LMO2 gene is involved in T-cell acute leukaemia (T-ALL) in children with chromosomal translocations t(11;14)(p13;q11) or (7;11)(q35;p13). Transgenic expression of Lmo2 in T cells results in clonal tumours with long latency indicating that mutations in other genes are required for the development of overt tumours. RAG V-D-J recombinase can mediate genetic transposition and thus might create the secondary mutations necessary for T-ALL. Tumour development was compared in Lmo2 transgenic mice in the presence or absence of the Rag1 gene. No difference was observed in the rate of tumour formation nor in tumour histology in Lmo2-transgenic mice with or without Rag1. We conclude that, in this model, RAG recombinase is not a major mediator of mutations needed for T cell tumorigenesis and that antigen binding to alpha-beta or to gamma-delta T cell receptor does not play a role in tumorigenesis. The driving force behind the mutational process involved in this transgenic model remains obscure. |
| first_indexed | 2024-03-06T21:28:14Z |
| format | Journal article |
| id | oxford-uuid:43d11543-d7d5-4a11-a122-cb0ea7a1281c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:28:14Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:43d11543-d7d5-4a11-a122-cb0ea7a1281c2022-03-26T14:57:45ZT cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:43d11543-d7d5-4a11-a122-cb0ea7a1281cEnglishSymplectic Elements at Oxford2001Drynan, LHamilton, TRabbitts, TThe LMO2 gene is involved in T-cell acute leukaemia (T-ALL) in children with chromosomal translocations t(11;14)(p13;q11) or (7;11)(q35;p13). Transgenic expression of Lmo2 in T cells results in clonal tumours with long latency indicating that mutations in other genes are required for the development of overt tumours. RAG V-D-J recombinase can mediate genetic transposition and thus might create the secondary mutations necessary for T-ALL. Tumour development was compared in Lmo2 transgenic mice in the presence or absence of the Rag1 gene. No difference was observed in the rate of tumour formation nor in tumour histology in Lmo2-transgenic mice with or without Rag1. We conclude that, in this model, RAG recombinase is not a major mediator of mutations needed for T cell tumorigenesis and that antigen binding to alpha-beta or to gamma-delta T cell receptor does not play a role in tumorigenesis. The driving force behind the mutational process involved in this transgenic model remains obscure. |
| spellingShingle | Drynan, L Hamilton, T Rabbitts, T T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity. |
| title | T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity. |
| title_full | T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity. |
| title_fullStr | T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity. |
| title_full_unstemmed | T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity. |
| title_short | T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity. |
| title_sort | t cell tumorigenesis in lmo2 transgenic mice is independent of v d j recombinase activity |
| work_keys_str_mv | AT drynanl tcelltumorigenesisinlmo2transgenicmiceisindependentofvdjrecombinaseactivity AT hamiltont tcelltumorigenesisinlmo2transgenicmiceisindependentofvdjrecombinaseactivity AT rabbittst tcelltumorigenesisinlmo2transgenicmiceisindependentofvdjrecombinaseactivity |