T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.
The LMO2 gene is involved in T-cell acute leukaemia (T-ALL) in children with chromosomal translocations t(11;14)(p13;q11) or (7;11)(q35;p13). Transgenic expression of Lmo2 in T cells results in clonal tumours with long latency indicating that mutations in other genes are required for the development...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2001
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