T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.

Antzeko izenburuak

• An antibody inhibitor of the LMO2-protein complex blocks its normal and tumorigenic functions.
  nork: Nam, C, et al.
  Argitaratua: (2008)
• The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development.
  nork: McCormack, M, et al.
  Argitaratua: (2003)
• Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.
  nork: Tse, E, et al.
  Argitaratua: (2004)
• Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia.
  nork: Appert, A, et al.
  Argitaratua: (2009)
• The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice.
  nork: Yamada, Y, et al.
  Argitaratua: (2000)