T cell tumorigenesis in Lmo2 transgenic mice is independent of V-D-J recombinase activity.

The LMO2 gene is involved in T-cell acute leukaemia (T-ALL) in children with chromosomal translocations t(11;14)(p13;q11) or (7;11)(q35;p13). Transgenic expression of Lmo2 in T cells results in clonal tumours with long latency indicating that mutations in other genes are required for the development...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính: Drynan, L, Hamilton, T, Rabbitts, T
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2001