Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy
<p style="text-align:justify;"> The safety of daily application of N, N-diethyl-m-toluamide (DEET) (1.7 g of DEET/day) in the second and third trimesters of pregnancy was assessed as part of a double-blind, randomized, therapeutic trial of insect repellents for the prevention of mal...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Jezik: | English |
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American Society of Tropical Medicine and Hygiene
2001
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| _version_ | 1826269650355224576 |
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| author | McGready, R Hamilton, K Simpson, J Cho, T Luxemburger, C Edwards, R Looareesuwan, S White, N Nosten, F Lindsay, S |
| author_facet | McGready, R Hamilton, K Simpson, J Cho, T Luxemburger, C Edwards, R Looareesuwan, S White, N Nosten, F Lindsay, S |
| author_sort | McGready, R |
| collection | OXFORD |
| description | <p style="text-align:justify;"> The safety of daily application of N, N-diethyl-m-toluamide (DEET) (1.7 g of DEET/day) in the second and third trimesters of pregnancy was assessed as part of a double-blind, randomized, therapeutic trial of insect repellents for the prevention of malaria in pregnancy (n = 897). No adverse neurologic, gastrointestinal, or dermatologic effects were observed for women who applied a median total dose of 214.2 g of DEET per pregnancy (range = 0-345.1 g). DEET crossed the placenta and was detected in 8% (95% confidence interval = 2.6-18.2) of cord blood samples from a randomly selected subgroup of DEET users (n = 50). No adverse effects on survival, growth, or development at birth, or at one year, were found. This is the first study to document the safety of DEET applied regularly in the second and third trimesters of pregnancy. The results suggest that the risk of DEET accumulating in the fetus is low and that DEET is safe to use in later pregnancy. </p> |
| first_indexed | 2024-03-06T21:28:24Z |
| format | Journal article |
| id | oxford-uuid:43ddfbad-baba-43fa-8d81-68ff716f9a8c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:28:24Z |
| publishDate | 2001 |
| publisher | American Society of Tropical Medicine and Hygiene |
| record_format | dspace |
| spelling | oxford-uuid:43ddfbad-baba-43fa-8d81-68ff716f9a8c2022-03-26T14:58:06ZSafety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:43ddfbad-baba-43fa-8d81-68ff716f9a8cEnglishSymplectic Elements at OxfordAmerican Society of Tropical Medicine and Hygiene2001McGready, RHamilton, KSimpson, JCho, TLuxemburger, CEdwards, RLooareesuwan, SWhite, NNosten, FLindsay, S <p style="text-align:justify;"> The safety of daily application of N, N-diethyl-m-toluamide (DEET) (1.7 g of DEET/day) in the second and third trimesters of pregnancy was assessed as part of a double-blind, randomized, therapeutic trial of insect repellents for the prevention of malaria in pregnancy (n = 897). No adverse neurologic, gastrointestinal, or dermatologic effects were observed for women who applied a median total dose of 214.2 g of DEET per pregnancy (range = 0-345.1 g). DEET crossed the placenta and was detected in 8% (95% confidence interval = 2.6-18.2) of cord blood samples from a randomly selected subgroup of DEET users (n = 50). No adverse effects on survival, growth, or development at birth, or at one year, were found. This is the first study to document the safety of DEET applied regularly in the second and third trimesters of pregnancy. The results suggest that the risk of DEET accumulating in the fetus is low and that DEET is safe to use in later pregnancy. </p> |
| spellingShingle | McGready, R Hamilton, K Simpson, J Cho, T Luxemburger, C Edwards, R Looareesuwan, S White, N Nosten, F Lindsay, S Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy |
| title | Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy |
| title_full | Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy |
| title_fullStr | Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy |
| title_full_unstemmed | Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy |
| title_short | Safety of the insect repellent N,N-diethyl-M-toluamide (DEET) in pregnancy |
| title_sort | safety of the insect repellent n n diethyl m toluamide deet in pregnancy |
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