Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta.

Solution structure of the third TB domain from LTBP1 provides insight into assembly of the large latent complex that sequesters latent TGF-beta.

Almost all TGF-beta is secreted as part of a large latent complex. This complex is formed from three molecules, a latent transforming growth factor-beta binding protein (LTBP), which plays roles in targeting and activation, a latency associated peptide (LAP), which regulates latency, and the TGF-bet...

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Bibliographic Details
Main Authors: Lack, J, O'Leary, J, Knott, V, Yuan, X, Rifkin, D, Handford, P, Downing, A
Format: Journal article
Language:English
Published: 2003

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