Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes.
In fasting nondiabetic subjects, insulin is secreted in regular pulses every 12 to 15 minutes, but patients with non-insulin-dependent diabetes lack regular oscillatory insulin secretion. To investigate whether abnormal insulin oscillations are an early feature of diabetes, we studied 10 minimally g...
Autores principales: | O'Rahilly, S, Turner, R, Matthews, DR |
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Formato: | Journal article |
Lenguaje: | English |
Publicado: |
1988
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