Genome sequence, comparative analysis and haplotype structure of the domestic dog.
Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show gre...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1826269738505863168 |
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| author | Lindblad-Toh, K Wade, C Mikkelsen, T Karlsson, E Jaffe, D Kamal, M Clamp, M Chang, J Kulbokas, E Zody, M Mauceli, E Xie, X Breen, M Wayne, R Ostrander, E Ponting, C Galibert, F Smith, DR DeJong, P Kirkness, E Alvarez, P Biagi, T Brockman, W Butler, J Chin, C |
| author_facet | Lindblad-Toh, K Wade, C Mikkelsen, T Karlsson, E Jaffe, D Kamal, M Clamp, M Chang, J Kulbokas, E Zody, M Mauceli, E Xie, X Breen, M Wayne, R Ostrander, E Ponting, C Galibert, F Smith, DR DeJong, P Kirkness, E Alvarez, P Biagi, T Brockman, W Butler, J Chin, C |
| author_sort | Lindblad-Toh, K |
| collection | OXFORD |
| description | Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health. |
| first_indexed | 2024-03-06T21:29:48Z |
| format | Journal article |
| id | oxford-uuid:444d6119-dc59-4f9c-8d0d-525e9ccad829 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:29:48Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:444d6119-dc59-4f9c-8d0d-525e9ccad8292022-03-26T15:00:50ZGenome sequence, comparative analysis and haplotype structure of the domestic dog.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:444d6119-dc59-4f9c-8d0d-525e9ccad829EnglishSymplectic Elements at Oxford2005Lindblad-Toh, KWade, CMikkelsen, TKarlsson, EJaffe, DKamal, MClamp, MChang, JKulbokas, EZody, MMauceli, EXie, XBreen, MWayne, ROstrander, EPonting, CGalibert, FSmith, DRDeJong, PKirkness, EAlvarez, PBiagi, TBrockman, WButler, JChin, CHere we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health. |
| spellingShingle | Lindblad-Toh, K Wade, C Mikkelsen, T Karlsson, E Jaffe, D Kamal, M Clamp, M Chang, J Kulbokas, E Zody, M Mauceli, E Xie, X Breen, M Wayne, R Ostrander, E Ponting, C Galibert, F Smith, DR DeJong, P Kirkness, E Alvarez, P Biagi, T Brockman, W Butler, J Chin, C Genome sequence, comparative analysis and haplotype structure of the domestic dog. |
| title | Genome sequence, comparative analysis and haplotype structure of the domestic dog. |
| title_full | Genome sequence, comparative analysis and haplotype structure of the domestic dog. |
| title_fullStr | Genome sequence, comparative analysis and haplotype structure of the domestic dog. |
| title_full_unstemmed | Genome sequence, comparative analysis and haplotype structure of the domestic dog. |
| title_short | Genome sequence, comparative analysis and haplotype structure of the domestic dog. |
| title_sort | genome sequence comparative analysis and haplotype structure of the domestic dog |
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