Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.
We herein report a faster and less cumbersome synthesis of the biologically attractive, alpha-galactosyl ceramide (alpha-GalCer), known as KRN7000, and its analogues. More importantly, the use of a silicon tethered intramolecular glycosylation reaction gave easy access to the diglycosyl ceramide Gal...
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Detalhes bibliográficos
| Main Authors: |
Veerapen, N,
Brigl, M,
Garg, S,
Cerundolo, V,
Cox, L,
Brenner, M,
Besra, G |
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| Formato: | Journal article
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| Idioma: | English |
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| Publicado em: |
2009
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