Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.
We herein report a faster and less cumbersome synthesis of the biologically attractive, alpha-galactosyl ceramide (alpha-GalCer), known as KRN7000, and its analogues. More importantly, the use of a silicon tethered intramolecular glycosylation reaction gave easy access to the diglycosyl ceramide Gal...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797065547516477440 |
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| author | Veerapen, N Brigl, M Garg, S Cerundolo, V Cox, L Brenner, M Besra, G |
| author_facet | Veerapen, N Brigl, M Garg, S Cerundolo, V Cox, L Brenner, M Besra, G |
| author_sort | Veerapen, N |
| collection | OXFORD |
| description | We herein report a faster and less cumbersome synthesis of the biologically attractive, alpha-galactosyl ceramide (alpha-GalCer), known as KRN7000, and its analogues. More importantly, the use of a silicon tethered intramolecular glycosylation reaction gave easy access to the diglycosyl ceramide Gal(alpha1-->2)GalCer, which has been shown to require uptake and processing to the biologically active alpha-GalCer derivative. |
| first_indexed | 2024-03-06T21:30:11Z |
| format | Journal article |
| id | oxford-uuid:446f1d9a-250f-45c6-b221-731836abcf96 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:30:11Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:446f1d9a-250f-45c6-b221-731836abcf962022-03-26T15:01:30ZSynthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:446f1d9a-250f-45c6-b221-731836abcf96EnglishSymplectic Elements at Oxford2009Veerapen, NBrigl, MGarg, SCerundolo, VCox, LBrenner, MBesra, GWe herein report a faster and less cumbersome synthesis of the biologically attractive, alpha-galactosyl ceramide (alpha-GalCer), known as KRN7000, and its analogues. More importantly, the use of a silicon tethered intramolecular glycosylation reaction gave easy access to the diglycosyl ceramide Gal(alpha1-->2)GalCer, which has been shown to require uptake and processing to the biologically active alpha-GalCer derivative. |
| spellingShingle | Veerapen, N Brigl, M Garg, S Cerundolo, V Cox, L Brenner, M Besra, G Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. |
| title | Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. |
| title_full | Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. |
| title_fullStr | Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. |
| title_full_unstemmed | Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. |
| title_short | Synthesis and biological activity of alpha-galactosyl ceramide KRN7000 and galactosyl (alpha1-->2) galactosyl ceramide. |
| title_sort | synthesis and biological activity of alpha galactosyl ceramide krn7000 and galactosyl alpha1 gt 2 galactosyl ceramide |
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