The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

Matching oxygen consumption and supply represents a fundamental challenge to multicellular organisms. HIF-1 is a transcription complex which is emerging as a key mediator of oxygen homeostasis. HIF-1 controls the expression of many genes, including erythropoietin, angiogenic growth factors, glucose...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Maxwell, P, Pugh, C, Ratcliffe, P
Μορφή:	Conference item
Έκδοση:	2001

Παρόμοια τεκμήρια

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
ανά: Hon, W, κ.ά.
Έκδοση: (2002)

The interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease-causing pVHL mutants.
ανά: Maher, E, κ.ά.
Έκδοση: (1999)

Interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease causing pVHL mutants
ανά: Clifford, S, κ.ά.
Έκδοση: (1999)

Effects of point mutations in pVHL on the binding of HIF-1α.
ανά: Domene, C, κ.ά.
Έκδοση: (2012)

Effects of point mutations in pVHL on the binding of HIF-1α
ανά: Domene, C, κ.ά.
Έκδοση: (2012)

Histone deacetylase inhibitor induced pVHL-independent degradation of HIF-1α and hierarchical quality control of pVHL via chaperone system.
ανά: Jieming Ni, κ.ά.
Έκδοση: (2021-01-01)

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
ανά: Mole, D, κ.ά.
Έκδοση: (2002)

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.
ανά: Clifford, S, κ.ά.
Έκδοση: (2001)

Inhibition of HIF2α Protein Suppresses pVHL-Driven Tumor Growth.
Έκδοση: (2003-12-01)

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.
ανά: Keiichi Kondo, κ.ά.
Έκδοση: (2003-12-01)

The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.
ανά: Clifford, S, κ.ά.
Έκδοση: (2001)

pVHL mediates K63-linked ubiquitination of nCLU.
ανά: Jing Xue, κ.ά.
Έκδοση: (2012-01-01)

Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes.
ανά: Miao Teng, κ.ά.
Έκδοση: (2012-01-01)

HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
ανά: Daniel Tarade, κ.ά.
Έκδοση: (2018-08-01)

Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha.
ανά: Illingworth, C, κ.ά.
Έκδοση: (2010)

MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma
ανά: Shouhua Zhang, κ.ά.
Έκδοση: (2023-01-01)

COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70.
ανά: Bart van de Sluis, κ.ά.
Έκδοση: (2009-10-01)

Genetic and Epigenetic Mechanisms Deregulate the CRL2pVHL Complex in Hepatocellular Carcinoma
ανά: Brenda C. Minatel, κ.ά.
Έκδοση: (2022-05-01)

Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer
ανά: Meng-Chuan Chen, κ.ά.
Έκδοση: (2017-07-01)

Up-regulation of pVHL along with down-regulation of HIF-1α by NDRG2 expression attenuates proliferation and invasion in renal cancer cells.
ανά: Lei Gao, κ.ά.
Έκδοση: (2013-01-01)

DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma
ανά: Xiaoming Dai, κ.ά.
Έκδοση: (2020-04-01)

The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer
ανά: Giovanni Minervini, κ.ά.
Έκδοση: (2020-07-01)

Identification and Functional Characterization of pVHL-Dependent Cell Surface Proteins in Renal Cell Carcinoma
ανά: Gunther Boysen, κ.ά.
Έκδοση: (2012-06-01)

Retraction. Up-regulation of pVHL along with down-regulation of HIF-1α by NDRG2 expression attenuates proliferation and invasion in renal cancer cells.
Έκδοση: (2014-01-01)

Author Correction: pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines
ανά: Javier Sevilla-Montero, κ.ά.
Έκδοση: (2023-05-01)

Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis
ανά: Xinxin Liu, κ.ά.
Έκδοση: (2020-04-01)

Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC).
ανά: Benedicte Martin, κ.ά.
Έκδοση: (2013-01-01)

VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF-Independent Actions
ανά: Cecilia Mathó, κ.ά.
Έκδοση: (2022-03-01)

Correction: Identification of pVHL as a Novel Substrate for Aurora-A in Clear Cell Renal Cell Carcinoma (ccRCC)
Έκδοση: (2014-01-01)

Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium
ανά: Hisashi Hasegawa, κ.ά.
Έκδοση: (2017-05-01)

Correction: Identification of pVHL as a Novel Substrate for Aurora-A in Clear Cell Renal Cell Carcinoma (ccRCC).
ανά: Benedicte Martin, κ.ά.
Έκδοση: (2014-01-01)

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
ανά: Maxwell, P, κ.ά.
Έκδοση: (1999)

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
ανά: Mole, D, κ.ά.
Έκδοση: (2001)

Correction to: Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma
ανά: Kai Guo, κ.ά.
Έκδοση: (2022-06-01)

Activation of the HIF pathway in cancer.
ανά: Maxwell, P, κ.ά.
Έκδοση: (2001)

Targeting tumors through the HIF system.
ανά: Ratcliffe, P, κ.ά.
Έκδοση: (2000)

Oxygen mediated gene regulation
ανά: Pugh, C, κ.ά.
Έκδοση: (2002)

Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
ανά: Daniel Tarade, κ.ά.
Έκδοση: (2019-07-01)

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.
ανά: Mandriota, S, κ.ά.
Έκδοση: (2002)

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
ανά: Foxler, D, κ.ά.
Έκδοση: (2012)