The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

The pVHL-hIF-1 system. A key mediator of oxygen homeostasis.

Matching oxygen consumption and supply represents a fundamental challenge to multicellular organisms. HIF-1 is a transcription complex which is emerging as a key mediator of oxygen homeostasis. HIF-1 controls the expression of many genes, including erythropoietin, angiogenic growth factors, glucose...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Maxwell, P, Pugh, C, Ratcliffe, P
Формат:	Conference item
Хэвлэсэн:	2001

Ижил төстэй зүйлс

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
-н: Hon, W, зэрэг
Хэвлэсэн: (2002)

The interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease-causing pVHL mutants.
-н: Maher, E, зэрэг
Хэвлэсэн: (1999)

Interaction between the von Hippel-Lindau gene product (pVHL) and hypoxia-inducible factor 1 is disrupted by disease causing pVHL mutants
-н: Clifford, S, зэрэг
Хэвлэсэн: (1999)

Effects of point mutations in pVHL on the binding of HIF-1α.
-н: Domene, C, зэрэг
Хэвлэсэн: (2012)

Effects of point mutations in pVHL on the binding of HIF-1α
-н: Domene, C, зэрэг
Хэвлэсэн: (2012)

Histone deacetylase inhibitor induced pVHL-independent degradation of HIF-1α and hierarchical quality control of pVHL via chaperone system.
-н: Jieming Ni, зэрэг
Хэвлэсэн: (2021-01-01)

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
-н: Mole, D, зэрэг
Хэвлэсэн: (2002)

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.
-н: Clifford, S, зэрэг
Хэвлэсэн: (2001)

Inhibition of HIF2α Protein Suppresses pVHL-Driven Tumor Growth.
Хэвлэсэн: (2003-12-01)

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.
-н: Keiichi Kondo, зэрэг
Хэвлэсэн: (2003-12-01)

The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma.
-н: Clifford, S, зэрэг
Хэвлэсэн: (2001)

pVHL mediates K63-linked ubiquitination of nCLU.
-н: Jing Xue, зэрэг
Хэвлэсэн: (2012-01-01)

Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway in hypoxic cardiomyocytes.
-н: Miao Teng, зэрэг
Хэвлэсэн: (2012-01-01)

HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease
-н: Daniel Tarade, зэрэг
Хэвлэсэн: (2018-08-01)

Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha.
-н: Illingworth, C, зэрэг
Хэвлэсэн: (2010)

MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma
-н: Shouhua Zhang, зэрэг
Хэвлэсэн: (2023-01-01)

COMMD1 Promotes pVHL and O2-Independent Proteolysis of HIF-1alpha via HSP90/70.
-н: Bart van de Sluis, зэрэг
Хэвлэсэн: (2009-10-01)

Genetic and Epigenetic Mechanisms Deregulate the CRL2pVHL Complex in Hepatocellular Carcinoma
-н: Brenda C. Minatel, зэрэг
Хэвлэсэн: (2022-05-01)

Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer
-н: Meng-Chuan Chen, зэрэг
Хэвлэсэн: (2017-07-01)

Up-regulation of pVHL along with down-regulation of HIF-1α by NDRG2 expression attenuates proliferation and invasion in renal cancer cells.
-н: Lei Gao, зэрэг
Хэвлэсэн: (2013-01-01)

DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma
-н: Xiaoming Dai, зэрэг
Хэвлэсэн: (2020-04-01)

The pVHL neglected functions, a tale of hypoxia-dependent and -independent regulations in cancer
-н: Giovanni Minervini, зэрэг
Хэвлэсэн: (2020-07-01)

Identification and Functional Characterization of pVHL-Dependent Cell Surface Proteins in Renal Cell Carcinoma
-н: Gunther Boysen, зэрэг
Хэвлэсэн: (2012-06-01)

Retraction. Up-regulation of pVHL along with down-regulation of HIF-1α by NDRG2 expression attenuates proliferation and invasion in renal cancer cells.
Хэвлэсэн: (2014-01-01)

Author Correction: pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines
-н: Javier Sevilla-Montero, зэрэг
Хэвлэсэн: (2023-05-01)

Deubiquitylase OTUD6B Governs pVHL Stability in an Enzyme‐Independent Manner and Suppresses Hepatocellular Carcinoma Metastasis
-н: Xinxin Liu, зэрэг
Хэвлэсэн: (2020-04-01)

Identification of pVHL as a novel substrate for Aurora-A in clear cell renal cell carcinoma (ccRCC).
-н: Benedicte Martin, зэрэг
Хэвлэсэн: (2013-01-01)

VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF-Independent Actions
-н: Cecilia Mathó, зэрэг
Хэвлэсэн: (2022-03-01)

Correction: Identification of pVHL as a Novel Substrate for Aurora-A in Clear Cell Renal Cell Carcinoma (ccRCC)
Хэвлэсэн: (2014-01-01)

Expression of von Hippel–Lindau tumor suppressor protein (pVHL) characteristic of tongue cancer and proliferative lesions in tongue epithelium
-н: Hisashi Hasegawa, зэрэг
Хэвлэсэн: (2017-05-01)

Correction: Identification of pVHL as a Novel Substrate for Aurora-A in Clear Cell Renal Cell Carcinoma (ccRCC).
-н: Benedicte Martin, зэрэг
Хэвлэсэн: (2014-01-01)

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
-н: Maxwell, P, зэрэг
Хэвлэсэн: (1999)

Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
-н: Mole, D, зэрэг
Хэвлэсэн: (2001)

Correction to: Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma
-н: Kai Guo, зэрэг
Хэвлэсэн: (2022-06-01)

Activation of the HIF pathway in cancer.
-н: Maxwell, P, зэрэг
Хэвлэсэн: (2001)

Targeting tumors through the HIF system.
-н: Ratcliffe, P, зэрэг
Хэвлэсэн: (2000)

Oxygen mediated gene regulation
-н: Pugh, C, зэрэг
Хэвлэсэн: (2002)

Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α
-н: Daniel Tarade, зэрэг
Хэвлэсэн: (2019-07-01)

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.
-н: Mandriota, S, зэрэг
Хэвлэсэн: (2002)

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
-н: Foxler, D, зэрэг
Хэвлэсэн: (2012)