5-methyl-tetrahydrofolic acid increases nitric oxide bioavailability and decreases superoxide production by improving eNOS coupling in human vessels in vivo: Effects on intracellular tetrahydrobiopterin oxidation

Bibliographic Details
Main Authors:	Antoniades, C, Shirodaria, C, Leeson, P, Lee, J, Warrick, N, Ratnatunga, C, Pillai, R, Channon, K
Format:	Conference item
Published:	2006

5-methyl-tetrahydrofolate increases nitric oxide bioavailability and decreases superoxide production by improving eNOS coupling and preventing the intracellular oxidation of tetrahy-drobiopterin, in human vessels in vivo
by: Antoniades, C, et al.
Published: (2006)

5-Methyl-tetrahydrofolate acid improves endothelial function and decreases superoxide production by improving eNOS coupling and increasing tetrahydrobiopterin bioavailability in human vessels in vivo
by: Antoniades, C, et al.
Published: (2006)

Intravenous infusion of 5-methyl-tetrahydrofolate rapidly improves eNOS Coupling. In human vessels by increasing tetrahydrobiopterin bioavailability
by: Antoniades, C, et al.
Published: (2006)

5-methyl-tetrahydrofolate increases eNOS activity by preventing peroxynitrite-induced oxidation of tetrahydrobiopterin in human vessels
by: Antoniades, C, et al.
Published: (2006)

Chronic treatment with folic acid improves nitric oxide bioavailability and decreases superoxide production in human vessels, through tetrahydrobiopterin-mediated improvement of eNOS coupling
by: Antoniades, C, et al.
Published: (2007)

Genetic Polymorphism On Methyl-Tetrahydrofolate-Reductase Affects Vascular Superoxide Generation and Nitric Oxide Bioavailability By Regulating eNOS Coupling in Human Arteries and Veins
by: Antoniades, C, et al.
Published: (2009)

5-Methyl-tetrahydrofolic acid rapidly improves endothelial function and superoxide production in human atherosclerosis: Effects on tetrahyd robiopterin-dependent eNOS coupling
by: Antoniades, C, et al.
Published: (2006)

Plasma asymmetrical-dimethyl-arginine affects eNOS vascular superoxide radical production and nitric oxide bioavailability in human arteries and veins
by: Antoniades, C, et al.
Published: (2008)

Genetic Variability of Methyl-Tetrahydrofolate-Reductase Modifies eNOS Coupling in Human Arteries and Veins: Effects on Vascular Superoxide Generation and Nitric Oxide Bioavailabllity
by: Antoniades, C, et al.
Published: (2008)

The common genetic polymorphism C677T of methyltetrahydrofolate reductase regulates nitric oxide bioavailability and vascular superoxide production via modulation of eNOS coupling in human vessels
by: Antoniades, C, et al.
Published: (2007)

Low- and high- dose treatment with folic acid, equally improve endothelial function and decrease superoxide production in human vessels via tetrahydrobiopterin-mediated eNOS coupling
by: Antoniades, C, et al.
Published: (2007)

Polymorphism of MTHFR gene affects vascular redox and nitric oxide bioavailability by modifying eNOS coupling
by: Antoniades, C, et al.
Published: (2008)

5-methyl-tetrahydrofolate acid improves endothelial function and decreases superoxide production in vessels from patients with coronary artery disease
by: Antoniades, C, et al.
Published: (2006)

Genetic variability of MTHFR affects vascular redox and nitric oxide bioavailability in human vessels, by modifying eNOS coupling
by: Antoniades, C, et al.
Published: (2008)

Direct effects of 5-methyl-tetrahydrofolate on vascular endotheliurn and superoxide production in human arteries and veins
by: Antoniades, C, et al.
Published: (2006)

5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling.
by: Antoniades, C, et al.
Published: (2006)

Effects of 5-methyl-tetrahydrofolic acid on endothelial function and vascular superoxide production in human coronary artery disease
by: Antoniades, C, et al.
Published: (2006)

Rapid effects of 5-methyl-tetrahydrofolic acid on endothelial function and vascular superoxide production in human coronary artery disease
by: Antoniades, C, et al.
Published: (2006)

Plasma asymmetrical-dimethyl-arginine (ADMA) regulates nitric oxide bioavailability and vascular superoxide production in human vessels
by: Antoniades, C, et al.
Published: (2007)

Soluble CD40-ligand levels are associated with vascular superoxide production and eNOS coupling in human vessels: Interrelationships with homocysteine biosynthetic pathway
by: Antoniades, C, et al.
Published: (2008)

Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression.
by: Crabtree, M, et al.
Published: (2009)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
by: Alp, N, et al.
Published: (2004)

Oral Atorvastatin Treatment Improves NO Bioavailability and Vascular Redox State in the Human Arterial Wall, via a Tetrahydrobiopterin-Mediated Improvement of eNOS Coupling
by: Antoniades, C, et al.
Published: (2011)

RAPID, DIRECT EFFECTS OF STATIN TREATMENT ON ARTERIAL REDOX STATE AND NITRIC OXIDE BIOAVAILABILITY IN HUMAN ATHEROSCLEROSIS VIA TETRAHYDROBIOPTERIN-MEDIATED ENOS COUPLING
by: Antoniades, C, et al.
Published: (2011)

Tetrahydrobiopterin availability directly regulates eNOS coupling in tet-regulatable cells
by: Crabtree, M, et al.
Published: (2007)

Regulation of eNOS function by tetrahydrobiopterin in vascular disease
by: Channon, K
Published: (2004)

Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression.
by: Bendall, J, et al.
Published: (2005)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
by: Cai, S, et al.
Published: (2005)

A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.
by: Benson, M, et al.
Published: (2013)

Endothelial-targeted GTP cyclohydrolase I overexpression increases endothelial tetrahydrobiopterin levels and preserves eNOS coupling in eNOS overexpressing mice
by: Bendall, J, et al.
Published: (2004)

Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis.
by: Antoniades, C, et al.
Published: (2009)

Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.
by: Crabtree, M, et al.
Published: (2008)

Plasma asymmetrical-dimethyl-arginine (ADMA) as a regulator of vascular redox and nitric oxide bioavailability in human vessels
by: Antoniades, C, et al.
Published: (2007)

Rapid Effects of Atorvastatin on Tetrahydrobiopterin-Mediated eNOS Coupling in Human Arteries, is Mediated by Stimulation of Vascular GTP-Cyclohydrolase
by: Antoniades, C, et al.
Published: (2011)

Endothelial tetrahydrobiopterin (BH4) regulates eNOS coupling in vivo: Functional effects of BH4-eNOS stoichiometry in endothelial targeted transgenic mice
by: Bendall, J, et al.
Published: (2005)

Tetrahydrobiopterin- and glutathionylation-dependent regulation of eNOS coupling: Relationships revealed by eNOS glutathionylation mutants in cells with tet-regulated GTP cyclohydrolase I expression
by: Crabtree, M, et al.
Published: (2012)

Chronic treatment with folic acid improves endothelial function and decreases superoxide production in human vessels. A double blind placebo control study
by: Shirodaria, C, et al.
Published: (2005)

Tetrahydrobiopterin-dependent eNOS coupling determines vascular remodeling through accelerated endothelial regeneration
by: Ali, Z, et al.
Published: (2007)

Plasma levels of sCD40-ligand interact with homocysteine biosynthetic pathway and predict eNOS coupling in human vessels: effects on vascular redox state
by: Antoniades, C, et al.
Published: (2008)

Expression and functional analysis of endothelial nitric oxide synthase (eNOS) in human placenta.
by: Rossmanith, W, et al.
Published: (1999)

5-methyl-tetrahydrofolic acid increases nitric oxide bioavailability and decreases superoxide production by improving eNOS coupling in human vessels in vivo: Effects on intracellular tetrahydrobiopterin oxidation

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