Igh-6(-/-) (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens.
In the present study we evaluated the role of B cells in acquired immunity to Salmonella infection by using gene-targeted B-cell-deficient innately susceptible mice on a C57BL/6 background (Igh-6(-/-)). Igh-6(-/-) mice immunized with a live, attenuated aroA Salmonella enterica serovar Typhimurium va...
Main Authors: | Mastroeni, P, Simmons, C, Fowler, R, Hormaeche, C, Dougan, G |
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Format: | Journal article |
Sprog: | English |
Udgivet: |
2000
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Lignende værker
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Igh-6(-/-) (B-cell-deficient) mice fail to mount solid acquired resistance to oral challenge with virulent Salmonella enterica serovar typhimurium and show impaired Th1 T-cell responses to Salmonella antigens
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Salmonella enterica serovar Typhimurium interaction with dendritic cells: impact of the sifA gene.
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