Complex relationship between obesity and the fat mass and obesity locus
In the 21st century, obesity has become a serious problem because of increasing obese patients and numerous metabolic complications. The primary reasons for this situation are environmental and genetic factors. In 2007, FTO (fat mass and obesity associated) was the first gene identified through a ge...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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Ivyspring International Publisher
2017
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| _version_ | 1797065592713248768 |
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| author | Yang, Q Xiao, T Guo, J Su, Z |
| author_facet | Yang, Q Xiao, T Guo, J Su, Z |
| author_sort | Yang, Q |
| collection | OXFORD |
| description | In the 21st century, obesity has become a serious problem because of increasing obese patients and numerous metabolic complications. The primary reasons for this situation are environmental and genetic factors. In 2007, FTO (fat mass and obesity associated) was the first gene identified through a genome-wide association study (GWAS) associated with obesity in humans. Subsequently, a cluster of single nucleotide polymorphisms (SNPs) in the first intron of the FTO gene was discovered to be associated with BMI and body composition. Various studies have explored the mechanistic basis behind this association. Thus, emerging evidence showed that FTO plays a key role regulating adipose tissue development and functions in body size and composition. Recent prevalent research topic concentrated in the three neighboring genes of FTO: RPGRIP1L, IRX3 and IRX5, as having a functional link between obesity-associated common variants within FTO and the observed human phenotypes. The purpose of this review is to present a comprehensive picture of the impact of FTO on obesity susceptibility and to illuminate these new studies of FTO function in adipose tissue. |
| first_indexed | 2024-03-06T21:30:50Z |
| format | Journal article |
| id | oxford-uuid:44a02dd4-b256-406e-967b-ff51c692324a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:30:50Z |
| publishDate | 2017 |
| publisher | Ivyspring International Publisher |
| record_format | dspace |
| spelling | oxford-uuid:44a02dd4-b256-406e-967b-ff51c692324a2022-03-26T15:02:46ZComplex relationship between obesity and the fat mass and obesity locusJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:44a02dd4-b256-406e-967b-ff51c692324aEnglishSymplectic Elements at OxfordIvyspring International Publisher2017Yang, QXiao, TGuo, JSu, ZIn the 21st century, obesity has become a serious problem because of increasing obese patients and numerous metabolic complications. The primary reasons for this situation are environmental and genetic factors. In 2007, FTO (fat mass and obesity associated) was the first gene identified through a genome-wide association study (GWAS) associated with obesity in humans. Subsequently, a cluster of single nucleotide polymorphisms (SNPs) in the first intron of the FTO gene was discovered to be associated with BMI and body composition. Various studies have explored the mechanistic basis behind this association. Thus, emerging evidence showed that FTO plays a key role regulating adipose tissue development and functions in body size and composition. Recent prevalent research topic concentrated in the three neighboring genes of FTO: RPGRIP1L, IRX3 and IRX5, as having a functional link between obesity-associated common variants within FTO and the observed human phenotypes. The purpose of this review is to present a comprehensive picture of the impact of FTO on obesity susceptibility and to illuminate these new studies of FTO function in adipose tissue. |
| spellingShingle | Yang, Q Xiao, T Guo, J Su, Z Complex relationship between obesity and the fat mass and obesity locus |
| title | Complex relationship between obesity and the fat mass and obesity locus |
| title_full | Complex relationship between obesity and the fat mass and obesity locus |
| title_fullStr | Complex relationship between obesity and the fat mass and obesity locus |
| title_full_unstemmed | Complex relationship between obesity and the fat mass and obesity locus |
| title_short | Complex relationship between obesity and the fat mass and obesity locus |
| title_sort | complex relationship between obesity and the fat mass and obesity locus |
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