Development of selective CBP/P300 benzoxazepine bromodomain inhibitors

Development of selective CBP/P300 benzoxazepine bromodomain inhibitors

CBP (CREB (cAMP responsive element binding protein) binding protein (CREBBP)) and P300 (adenovirus E1A-associated 300 kDa protein) are two closely related histone acetyltransferases (HATs) that play a key role in the regulation of gene transcription. Both proteins contain a bromodomain flanking the...

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Bibliographic Details
Main Authors:	Popp, T, Tallant, C, Rogers, C, Fedorov, O, Brennan, P, Müller, S, Knapp, S, Bracher, F
Format:	Journal article
Language:	English
Published:	American Chemical Society 2016

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