Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence.
Persistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95% of those infected at birth and 15% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in approxima...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2006
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| _version_ | 1797065600281870336 |
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| author | Frodsham, A Zhang, L Dumpis, U Taib, N Best, S Durham, A Hennig, B Hellier, S Knapp, S Wright, M Chiaramonte, M Bell, J Graves, M Whittle, H Thomas, H Thursz, MR Hill, A |
| author_facet | Frodsham, A Zhang, L Dumpis, U Taib, N Best, S Durham, A Hennig, B Hellier, S Knapp, S Wright, M Chiaramonte, M Bell, J Graves, M Whittle, H Thomas, H Thursz, MR Hill, A |
| author_sort | Frodsham, A |
| collection | OXFORD |
| description | Persistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95% of those infected at birth and 15% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in approximately 350 million persistent carriers worldwide. Via a whole genome scan in Gambian families, we have identified a major susceptibility locus as a cluster of class II cytokine receptor genes on chromosome 21q22. Coding changes in two of these genes, the type I IFN receptor gene, IFN-AR2, and the IL-10RB gene that encodes a receptor chain for IL-10-related cytokines including the IFN-lambdas, are associated with viral clearance (haplotype P value = 0.0003), and in vitro assays support functional roles for these variants in receptor signaling. |
| first_indexed | 2024-03-06T21:30:57Z |
| format | Journal article |
| id | oxford-uuid:44a7b196-9eeb-48c4-9484-ca522e3e78f2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:30:57Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:44a7b196-9eeb-48c4-9484-ca522e3e78f22022-03-26T15:03:00ZClass II cytokine receptor gene cluster is a major locus for hepatitis B persistence.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:44a7b196-9eeb-48c4-9484-ca522e3e78f2EnglishSymplectic Elements at Oxford2006Frodsham, AZhang, LDumpis, UTaib, NBest, SDurham, AHennig, BHellier, SKnapp, SWright, MChiaramonte, MBell, JGraves, MWhittle, HThomas, HThursz, MRHill, APersistent hepatitis B virus infection is a major risk factor for hepatocellular carcinoma, the most frequent cancer in some developing countries. Up to 95% of those infected at birth and 15% of those infected after the neonatal period fail to clear hepatitis B virus, together resulting in approximately 350 million persistent carriers worldwide. Via a whole genome scan in Gambian families, we have identified a major susceptibility locus as a cluster of class II cytokine receptor genes on chromosome 21q22. Coding changes in two of these genes, the type I IFN receptor gene, IFN-AR2, and the IL-10RB gene that encodes a receptor chain for IL-10-related cytokines including the IFN-lambdas, are associated with viral clearance (haplotype P value = 0.0003), and in vitro assays support functional roles for these variants in receptor signaling. |
| spellingShingle | Frodsham, A Zhang, L Dumpis, U Taib, N Best, S Durham, A Hennig, B Hellier, S Knapp, S Wright, M Chiaramonte, M Bell, J Graves, M Whittle, H Thomas, H Thursz, MR Hill, A Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. |
| title | Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. |
| title_full | Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. |
| title_fullStr | Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. |
| title_full_unstemmed | Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. |
| title_short | Class II cytokine receptor gene cluster is a major locus for hepatitis B persistence. |
| title_sort | class ii cytokine receptor gene cluster is a major locus for hepatitis b persistence |
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