A large polysaccharide produced by helicobacter hepaticus induces an anti-inflammatory gene signature in macrophages
Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal mic...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2017
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| _version_ | 1797065608827764736 |
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| author | Danne, C Ryzhakov, G Martínez-López, M Ilott, N Franchini, F Cuskin, F Lowe, E Bullers, S Arthur, J Powrie, F |
| author_facet | Danne, C Ryzhakov, G Martínez-López, M Ilott, N Franchini, F Cuskin, F Lowe, E Bullers, S Arthur, J Powrie, F |
| author_sort | Danne, C |
| collection | OXFORD |
| description | Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tolerated by the host. In the absence of an intact IL-10 signaling, H. hepaticus induces an IL-23-driven inflammatory response in the intestine. Here we investigate the interactions between H. hepaticus and host immune cells that may promote mutualism, and the microbe-derived molecule(s) involved. Our results show that H. hepaticus triggers early IL-10 induction in intestinal macrophages and produces a large soluble polysaccharide that activates a specific MSK/CREB-dependent anti-inflammatory and repair gene signature via the receptor TLR2. These data identify a host-bacterial interaction that promotes mutualistic mechanisms at the intestinal interface. Further understanding of this pathway may provide novel prevention and treatment strategies for inflammatory bowel disease. |
| first_indexed | 2024-03-06T21:31:04Z |
| format | Journal article |
| id | oxford-uuid:44b2ba0f-9858-48a1-9bf0-c906bb676e03 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:31:04Z |
| publishDate | 2017 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:44b2ba0f-9858-48a1-9bf0-c906bb676e032022-03-26T15:03:16ZA large polysaccharide produced by helicobacter hepaticus induces an anti-inflammatory gene signature in macrophagesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:44b2ba0f-9858-48a1-9bf0-c906bb676e03EnglishSymplectic Elements at OxfordCell Press2017Danne, CRyzhakov, GMartínez-López, MIlott, NFranchini, FCuskin, FLowe, EBullers, SArthur, JPowrie, FInteractions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tolerated by the host. In the absence of an intact IL-10 signaling, H. hepaticus induces an IL-23-driven inflammatory response in the intestine. Here we investigate the interactions between H. hepaticus and host immune cells that may promote mutualism, and the microbe-derived molecule(s) involved. Our results show that H. hepaticus triggers early IL-10 induction in intestinal macrophages and produces a large soluble polysaccharide that activates a specific MSK/CREB-dependent anti-inflammatory and repair gene signature via the receptor TLR2. These data identify a host-bacterial interaction that promotes mutualistic mechanisms at the intestinal interface. Further understanding of this pathway may provide novel prevention and treatment strategies for inflammatory bowel disease. |
| spellingShingle | Danne, C Ryzhakov, G Martínez-López, M Ilott, N Franchini, F Cuskin, F Lowe, E Bullers, S Arthur, J Powrie, F A large polysaccharide produced by helicobacter hepaticus induces an anti-inflammatory gene signature in macrophages |
| title | A large polysaccharide produced by helicobacter hepaticus induces an anti-inflammatory gene signature in macrophages |
| title_full | A large polysaccharide produced by helicobacter hepaticus induces an anti-inflammatory gene signature in macrophages |
| title_fullStr | A large polysaccharide produced by helicobacter hepaticus induces an anti-inflammatory gene signature in macrophages |
| title_full_unstemmed | A large polysaccharide produced by helicobacter hepaticus induces an anti-inflammatory gene signature in macrophages |
| title_short | A large polysaccharide produced by helicobacter hepaticus induces an anti-inflammatory gene signature in macrophages |
| title_sort | large polysaccharide produced by helicobacter hepaticus induces an anti inflammatory gene signature in macrophages |
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