The immune response to intracerebral neural grafts.
Neural transplantation offers a potential therapeutic approach to a variety of neurological disorders, most notably those of a degenerative nature. However, the degree of immunological privilege (i.e. isolation from an immune response) in the brain, which is not absolute, may be a significant impedi...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1991
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| _version_ | 1826269825839661056 |
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| author | Sloan, D Wood, M Charlton, H |
| author_facet | Sloan, D Wood, M Charlton, H |
| author_sort | Sloan, D |
| collection | OXFORD |
| description | Neural transplantation offers a potential therapeutic approach to a variety of neurological disorders, most notably those of a degenerative nature. However, the degree of immunological privilege (i.e. isolation from an immune response) in the brain, which is not absolute, may be a significant impediment to the survival of histoincompatible grafts. The nature of this privilege, together with the specific immune events leading to neural graft rejection, are discussed. As a consequence of this immune-mediated rejection, immunosuppression in some form might be necessary to guarantee long-term graft survival. Various strategies are being explored to suppress the immune response to neural grafts, not only for future use in clinical therapies, but also to bring intracerebral allo- and xenotransplantation to the attention of the general neurobiologist. |
| first_indexed | 2024-03-06T21:31:13Z |
| format | Journal article |
| id | oxford-uuid:44bdf16a-4d86-414f-97a7-b6433314a27a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:31:13Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:44bdf16a-4d86-414f-97a7-b6433314a27a2022-03-26T15:03:36ZThe immune response to intracerebral neural grafts.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:44bdf16a-4d86-414f-97a7-b6433314a27aEnglishSymplectic Elements at Oxford1991Sloan, DWood, MCharlton, HNeural transplantation offers a potential therapeutic approach to a variety of neurological disorders, most notably those of a degenerative nature. However, the degree of immunological privilege (i.e. isolation from an immune response) in the brain, which is not absolute, may be a significant impediment to the survival of histoincompatible grafts. The nature of this privilege, together with the specific immune events leading to neural graft rejection, are discussed. As a consequence of this immune-mediated rejection, immunosuppression in some form might be necessary to guarantee long-term graft survival. Various strategies are being explored to suppress the immune response to neural grafts, not only for future use in clinical therapies, but also to bring intracerebral allo- and xenotransplantation to the attention of the general neurobiologist. |
| spellingShingle | Sloan, D Wood, M Charlton, H The immune response to intracerebral neural grafts. |
| title | The immune response to intracerebral neural grafts. |
| title_full | The immune response to intracerebral neural grafts. |
| title_fullStr | The immune response to intracerebral neural grafts. |
| title_full_unstemmed | The immune response to intracerebral neural grafts. |
| title_short | The immune response to intracerebral neural grafts. |
| title_sort | immune response to intracerebral neural grafts |
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