Growth hormone releasing hormone in the assessment and long-term treatment of growth hormone deficiency.
The secretion of hGH after the administration of the analogue of growth hormone releasing hormone, GHRH (1-29)NH2, to 8 normal adults and 41 short children has been studied. The children were classified on the basis of their hGH response to insulin-induced hypoglycaemia; 28 had severe hGH deficiency...
| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
1987
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| _version_ | 1826269841267359744 |
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| author | Ross, R Grossman, A Preece, M Savage, M Besser, G |
| author_facet | Ross, R Grossman, A Preece, M Savage, M Besser, G |
| author_sort | Ross, R |
| collection | OXFORD |
| description | The secretion of hGH after the administration of the analogue of growth hormone releasing hormone, GHRH (1-29)NH2, to 8 normal adults and 41 short children has been studied. The children were classified on the basis of their hGH response to insulin-induced hypoglycaemia; 28 had severe hGH deficiency (peak serum hGH less than 7 mIU/litre) and 13 had simple short stature (peak serum hGH greater than 15 mIU/litre). The hGH response to GHRH was similar in normal adults and short stature children, but significantly lower in the hGH deficient children. In 23 (82%) of the hGH deficient children the peak serum hGH in response to GHRH was greater than 7 mIU/litre (the maximum value seen during hypoglycaemia), and in 14 (50%) the peak serum hGH in response to GHRH was greater than 15 mIU/litre. This suggests that in the majority of hGH deficient children the defect in hGH secretion results from hypothalamic GHRH deficiency. The hGH responses of the short stature children to insulin-induced hypoglycaemia were mainly in the low range of normal, and the majority showed normal hGH responses to GHRH. Eighteen prepubertal children with definite hGH deficiency have been treated for 3-18 months with twice daily, subcutaneous injections of GHRH. This has promoted linear growth in 12 children, of whom 8 showed an increment in height velocity of 2-11 cm/year. GHRH provides a valuable method for the assessment of hGH secretion, but by itself it cannot be used to establish deficient hGH secretion; this requires a stimulation test that promotes hypothalamic GHRH secretion, such as insulin-induced hypoglycaemia. GHRH is a practical alternative therapy to hGH for some hGH-deficient children. |
| first_indexed | 2024-03-06T21:31:28Z |
| format | Journal article |
| id | oxford-uuid:44d0d82a-7a3c-41f4-9d92-1c27a156509d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:31:28Z |
| publishDate | 1987 |
| record_format | dspace |
| spelling | oxford-uuid:44d0d82a-7a3c-41f4-9d92-1c27a156509d2022-03-26T15:03:58ZGrowth hormone releasing hormone in the assessment and long-term treatment of growth hormone deficiency.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:44d0d82a-7a3c-41f4-9d92-1c27a156509dEnglishSymplectic Elements at Oxford1987Ross, RGrossman, APreece, MSavage, MBesser, GThe secretion of hGH after the administration of the analogue of growth hormone releasing hormone, GHRH (1-29)NH2, to 8 normal adults and 41 short children has been studied. The children were classified on the basis of their hGH response to insulin-induced hypoglycaemia; 28 had severe hGH deficiency (peak serum hGH less than 7 mIU/litre) and 13 had simple short stature (peak serum hGH greater than 15 mIU/litre). The hGH response to GHRH was similar in normal adults and short stature children, but significantly lower in the hGH deficient children. In 23 (82%) of the hGH deficient children the peak serum hGH in response to GHRH was greater than 7 mIU/litre (the maximum value seen during hypoglycaemia), and in 14 (50%) the peak serum hGH in response to GHRH was greater than 15 mIU/litre. This suggests that in the majority of hGH deficient children the defect in hGH secretion results from hypothalamic GHRH deficiency. The hGH responses of the short stature children to insulin-induced hypoglycaemia were mainly in the low range of normal, and the majority showed normal hGH responses to GHRH. Eighteen prepubertal children with definite hGH deficiency have been treated for 3-18 months with twice daily, subcutaneous injections of GHRH. This has promoted linear growth in 12 children, of whom 8 showed an increment in height velocity of 2-11 cm/year. GHRH provides a valuable method for the assessment of hGH secretion, but by itself it cannot be used to establish deficient hGH secretion; this requires a stimulation test that promotes hypothalamic GHRH secretion, such as insulin-induced hypoglycaemia. GHRH is a practical alternative therapy to hGH for some hGH-deficient children. |
| spellingShingle | Ross, R Grossman, A Preece, M Savage, M Besser, G Growth hormone releasing hormone in the assessment and long-term treatment of growth hormone deficiency. |
| title | Growth hormone releasing hormone in the assessment and long-term treatment of growth hormone deficiency. |
| title_full | Growth hormone releasing hormone in the assessment and long-term treatment of growth hormone deficiency. |
| title_fullStr | Growth hormone releasing hormone in the assessment and long-term treatment of growth hormone deficiency. |
| title_full_unstemmed | Growth hormone releasing hormone in the assessment and long-term treatment of growth hormone deficiency. |
| title_short | Growth hormone releasing hormone in the assessment and long-term treatment of growth hormone deficiency. |
| title_sort | growth hormone releasing hormone in the assessment and long term treatment of growth hormone deficiency |
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