Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia.
The Medical Research Council acute lymphoblastic leukaemia trials (UKALL X and XI) recruited 3,702 children with ALL between January 1985 and March 1997. Seventy-nine children had central nervous system (CNS) involvement in their first two relapses. Fourteen children survived at a median follow-up o...
| Egile Nagusiak: | , , , , , , , |
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| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
2003
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| _version_ | 1826269878960521216 |
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| author | Morris, E Harrison, G Bailey, C Hann, I Hill, F Gibson, B Richards, S Webb, D |
| author_facet | Morris, E Harrison, G Bailey, C Hann, I Hill, F Gibson, B Richards, S Webb, D |
| author_sort | Morris, E |
| collection | OXFORD |
| description | The Medical Research Council acute lymphoblastic leukaemia trials (UKALL X and XI) recruited 3,702 children with ALL between January 1985 and March 1997. Seventy-nine children had central nervous system (CNS) involvement in their first two relapses. Fourteen children survived at a median follow-up of 22 months from second relapse; seven (9%) in third remission, two in later remissions and five with disease. Factors predictive of survival from second relapse were site (isolated CNS was better than combined CNS, P = 0.02) and time from diagnosis to second CNS relapse (longer time was better, P = 0.004). Prognosis after second CNS relapse is extremely poor, and palliative therapy is appropriate. |
| first_indexed | 2024-03-06T21:32:05Z |
| format | Journal article |
| id | oxford-uuid:4502d878-0a71-4d3e-9311-62d6eaeef463 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:32:05Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:4502d878-0a71-4d3e-9311-62d6eaeef4632022-03-26T15:05:12ZPrognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:4502d878-0a71-4d3e-9311-62d6eaeef463EnglishSymplectic Elements at Oxford2003Morris, EHarrison, GBailey, CHann, IHill, FGibson, BRichards, SWebb, DThe Medical Research Council acute lymphoblastic leukaemia trials (UKALL X and XI) recruited 3,702 children with ALL between January 1985 and March 1997. Seventy-nine children had central nervous system (CNS) involvement in their first two relapses. Fourteen children survived at a median follow-up of 22 months from second relapse; seven (9%) in third remission, two in later remissions and five with disease. Factors predictive of survival from second relapse were site (isolated CNS was better than combined CNS, P = 0.02) and time from diagnosis to second CNS relapse (longer time was better, P = 0.004). Prognosis after second CNS relapse is extremely poor, and palliative therapy is appropriate. |
| spellingShingle | Morris, E Harrison, G Bailey, C Hann, I Hill, F Gibson, B Richards, S Webb, D Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia. |
| title | Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia. |
| title_full | Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia. |
| title_fullStr | Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia. |
| title_full_unstemmed | Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia. |
| title_short | Prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia. |
| title_sort | prognostic factors and outcome for children after second central nervous system relapse of acute lymphoblastic leukaemia |
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