The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.

Genome-wide association studies have identified a number of signals for both Type 2 Diabetes and related quantitative traits. For the majority of loci, the transition from association signal to mutational mechanism has been difficult to establish. Glucokinase (GCK) regulates glucose storage and disp...

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Bibliographic Details
Main Authors:	Beer, N, Tribble, N, McCulloch, L, Roos, C, Johnson, P, Orho-Melander, M, Gloyn, A
Format:	Journal article
Language:	English
Published:	Oxford University Press 2009

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