The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver.

Genome-wide association studies have identified a number of signals for both Type 2 Diabetes and related quantitative traits. For the majority of loci, the transition from association signal to mutational mechanism has been difficult to establish. Glucokinase (GCK) regulates glucose storage and disp...

書目詳細資料
Main Authors:	Beer, N, Tribble, N, McCulloch, L, Roos, C, Johnson, P, Orho-Melander, M, Gloyn, A
格式:	Journal article
語言:	English
出版:	Oxford University Press 2009

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