Chemical and biological studies on human oxygenases

Chemical and biological studies on human oxygenases

<p>As depicted in Chapter I, 2-oxoglutarate- (2OG) dependent oxygenases are ubiquitous in living systems and display a wide range of cellular functions, spanning metabolism, transcription, and translation. Although functionally diverse, the 2OG oxygenases share a high degree of structural simi...

Descripció completa

Dades bibliogràfiques
Autors principals:	Thinnes, C, Dr Cyrille C. Thinnes
Altres autors:	Schofield, C
Format:	Thesis
Idioma:	English
Publicat:	2014
Matèries:	Chemical biology Chemistry & allied sciences Business Entrepreneurship Structural genomics Oncology Biophysical chemistry Science and technology (business & management) Marketing Physical Sciences Pharmacology Cell Biology (see also Plant sciences) Management Biochemistry Enzymes Life Sciences Genetics (life sciences) Polymers Amino acid and peptide chemistry Organic synthesis Synthetic organic chemistry Organic chemistry Business and Management Protein chemistry Chemical kinetics Computer aided molecular and material design Biology

Ítems similars

NMR studies on 2-oxoglutarate oxygenases
per: Leung, IKH
Publicat: (2013)

Development of small molecule inhibitors of the bromodomain-histone interaction
per: Rooney, TPC
Publicat: (2014)

Olefin metathesis for site-selective protein modification
per: Lin, YA
Publicat: (2013)

Design and synthesis of myo-inositol (1,4,5)-trisphosphate receptor antagonists
per: Ye, Y
Publicat: (2013)

A glycopore for bacterial sensing
per: Shanley, SJ
Publicat: (2009)

Single-molecule chemistry studies with engineered alpha-hemolysin pores
per: Hammerstein, A
Publicat: (2011)

Developing inhibitors of bromodomain-histone interactions
per: Hewings, D
Publicat: (2014)

Interplay between 2-oxoglutarate oxygenases and cancer: studies on the aspartyl/asparaginyl-beta-hydroxylase
per: Pfeffer, I
Publicat: (2014)

Peptide targeting by spontaneous isopeptide bond formation
per: Zakeri, B, et al.
Publicat: (2011)

Kinetic and mechanistic studies of oxygen sensing Fe(II)/2-oxoglutarate dependent oxygenases
per: Tarhonskaya, H
Publicat: (2014)

Synthesis of Mycobacterium tuberculosis ATP synthase inhibitors
per: Pattarakiat, Seankongsuk
Publicat: (2022)

Studies on an N-terminal nucleophile hydrolase and enzymes of clavulanic acid biosynthesis
per: Iqbal, A
Publicat: (2008)

Mechanistic and inhibition studies on gamma-butyrobetaine hydroxylase
per: Rydzik, AM
Publicat: (2014)

Conformational control by intramolecular hydrogen bonding
per: Luccarelli, J, et al.
Publicat: (2013)

Enzymatic and structural insights into the mycobacterial alkylhydroperoxide reductase subunit C and repurposing of an antimalaria compound inhibiting the mycobacterial cytochrome BCC oxidase for tuberculosis disease
per: Chong, Sherilyn Shi Min
Publicat: (2020)

Asymmetric syntheses of β- and γ-amino acids
per: Zammit, C
Publicat: (2015)

Aziridinations of tethered allenes
per: Feast, GC
Publicat: (2011)

Alkaloids from transannular iodoaminations
per: Brock, E
Publicat: (2012)

Versatile synthetic strategies towards the development of novel neuroblastoma inhibitors and their analogues
per: Alishahi, S
Publicat: (2013)

Studies towards the stereoselective synthesis of alkenes
per: Arif, T
Publicat: (2011)

Analysis of potassium (K+) efflux systems (Kef) as an antibiotic target in pathogenic bacteria
per: Haslam, C
Publicat: (2019)

Exploring and exploiting selectivity in Rhodium-catalysed hydroacylation reactions
per: Poingdestre, SJ
Publicat: (2012)

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis
per: Hodgson, D, et al.
Publicat: (2008)

Enantiorecognition phenomena in asymmetric synthesis
per: Yin, J, et al.
Publicat: (2011)

Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.
per: Donohoe, T, et al.
Publicat: (2011)

Reaction engineering for protein modification: tools for chemistry and biology
per: Chalker, J
Publicat: (2011)

Design and synthesis of inositol phosphate-based probes
per: Slowey, A
Publicat: (2013)

The synthesis of branched sugars and iminosugars
per: Parry, LL
Publicat: (2011)

Asymmetric synthesis of α-alkylated aldehydes using chiral enamines
per: Kaka, N, et al.
Publicat: (2008)

Towards the total synthesis of calyciphylline A-type Daphniphyllum alkaloids
per: Michaelides, IN
Publicat: (2014)

Transition metal catalysed C-C bond formation via C-H functionalisation
per: Truscott, FR
Publicat: (2012)

Palladium mediated allylic fluorination
per: Hollingworth, C
Publicat: (2013)

Determining the structures of halogenated marine natural products by total synthesis
per: Dyson, BS
Publicat: (2011)

Tandem catalytic processes involving Rhodium-catalysed intermolecular hydroacylation
per: Lenden, P
Publicat: (2011)

Molecular dynamics simulation of the M2 helices within the nicotinic acetylcholine receptor transmembrane domain: structure and collective motions
Publicat: (2005)

Studies towards the total synthesis of manzamine A
per: Hawkins, A
Publicat: (2013)

Palladium-catalysed cascade cyclisation of alkynyl silanes and studies towards rubriflordilactone A
per: Cordonnier, M, et al.
Publicat: (2011)

The synthesis and biology of iminosugars and their precursors
per: Ayers, B, et al.
Publicat: (2014)

Discovery, characterization, and applications of cysteine-rich peptides from medicinal plants
per: Huang, Jiayi
Publicat: (2020)

Perylene-derived single-component organic nanoparticles with tunable emission : efficient anticancer drug carriers with real-time Monitoring of drug release
per: Li, Xin, et al.
Publicat: (2014)